Protective effect of melatonin on experimental spinal cord ischemia

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dc.authoridaydemir, songul/0000-0002-7921-0662
dc.authorwosidOZDEMIR, ISMAIL/KVY-3420-2024
dc.authorwosidaydemir, songul/AAA-4291-2021
dc.contributor.authorErten, SF
dc.contributor.authorKocak, A
dc.contributor.authorOzdemir, I
dc.contributor.authorAydemir, S
dc.contributor.authorColak, A
dc.contributor.authorReeder, BS
dc.date.accessioned2024-08-04T20:13:28Z
dc.date.available2024-08-04T20:13:28Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractStudy design: Experimental animal model to assess ischemic spinal cord injury following occlusion of the thoraco-abdominal aorta. Objectives: To measure whether melatonin administered to rabbits before and after occlusion exerts an effect on the repair of ischemia-reperfusion (IR) injury. Setting: Medical Biology Laboratory, Inonu University, Malatya, Turkey. Methods: Rabbits were divided into three IR treatment groups and one sham-operated (ShOp) control group. The three treatment groups had their infrarenal aorta temporarily occluded for 25 min, while the ShOp group had laparotomy without aortic occlusion. Melatonin was administered either 10 min before aortic occlusion or 10 min after the clamp was removed. Physiologic saline was administered to the control animals. After treatment, the animals were euthanized and lumbosacral spinal cord tissue was removed for the determination of relevant enzyme activities. Results: Malondialdehyde levels, indicating the extent of lipid peroxidation, were found to be significantly increased in the nonmelatonin treated (IR) group when compared to the ShOp group. Melatonin, whether given to pre- or post occlusion groups, suppressed malondialdehyde levels below that of the ShOp group. Catalase (CAT) and glutathione peroxidase (GSH-Px) enzyme activities were increased in the IR group compared to the ShOp group. Melatonin given preocclusion resulted in a significant decrease in both CAT and GSH-Px enzyme levels. The superoxide dismutase ( SOD) enzyme activity was decreased in the ischemia-reperfusion treatment group. However, the melatonin treatment increased SOD enzyme activity to levels approximating that of the ShOp group. Conclusion: To our knowledge, this is the first study that shows the effects of melatonin administered both pre- and postischemia on induced oxidative damage to injured spinal cords. Our data also expands on reports that melatonin administration may significantly reduce the incidence of spinal cord injury following temporary aortic occlusion.en_US
dc.identifier.doi10.1038/sj.sc.3101508
dc.identifier.endpage538en_US
dc.identifier.issn1362-4393
dc.identifier.issn1476-5624
dc.identifier.issue10en_US
dc.identifier.pmid14504608en_US
dc.identifier.scopus2-s2.0-0141956538en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage533en_US
dc.identifier.urihttps://doi.org/10.1038/sj.sc.3101508
dc.identifier.urihttps://hdl.handle.net/11616/93634
dc.identifier.volume41en_US
dc.identifier.wosWOS:000185535400002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofSpinal Corden_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcatalaseen_US
dc.subjectglutathione peroxidaseen_US
dc.subjectlipid peroxidationen_US
dc.subjectmelatoninen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjectspinal cord ischemiaen_US
dc.titleProtective effect of melatonin on experimental spinal cord ischemiaen_US
dc.typeArticleen_US

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