The effects of androstenediol and dehydroepiandrosterone on the immune response to BCG at puberty

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dc.authoridKutlu, Nurettin Onur/0000-0002-3306-6570
dc.authorwosidKutlu, Nurettin Onur/AAW-6196-2021
dc.contributor.authorKutlu, NO
dc.contributor.authorAkinci, A
dc.contributor.authorSönmezgöz, E
dc.contributor.authorTemel, I
dc.contributor.authorEvliyaoglu, E
dc.date.accessioned2024-08-04T20:13:21Z
dc.date.available2024-08-04T20:13:21Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn order to assess the effects of age-related changes of serum dehydroepiandrosterone sulphate (DHEAS) and androstenediol (AED) concentrations on BCG vaccination throughout the puberty period, we matched 41 prepubertal (mean age 8.63+/-1.36 years, range 8-14 years) and 43 pubertal (mean age 13.8+/-1.31 years, range 10-16 years) schoolchildren who were PPD negative and free of disease or medication known to affect immune function. The tuberculin test was performed 8 weeks after vaccination and tuberculin response and hormone levels were compared between prepubertal and pubertal subjects. We found a higher tuberculin response in the pubertal group when compared with the prepubertal ones. The pubertal children had 79.1 per cent tuberculin positivity compared with 46.4 per cent of prepubertal children (p<0.05). Diameters of induration of the tuberculin test among prepubertal students vs. pubertal students were 9.5+/-3.8 mm and 11.9+/-3.7 mm, respectively (p<0.005). Pubertal stage, testis volume, and pubic stage were also found to have significant effects on tuberculin test results. No difference was observed between both sexes with regard to responses of the tuberculin test in either the prepubertal or the pubertal group (p>0.05). DHEAS and AED levels in the tuberculin-positive subjects were found to be significantly higher than tuberculin-negative ones (p=0.040 and p=0.046, respectively). Among both these hormones, only AED levels were correlated with tuberculin test responses. These results suggest that AED may play a role in the immunity to BCG vaccination and further immunological investigations are warranted to provide support for this idea.en_US
dc.identifier.doi10.1093/tropej/49.3.181
dc.identifier.endpage185en_US
dc.identifier.issn0142-6338
dc.identifier.issue3en_US
dc.identifier.pmid12848211en_US
dc.identifier.scopus2-s2.0-0038787570en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage181en_US
dc.identifier.urihttps://doi.org/10.1093/tropej/49.3.181
dc.identifier.urihttps://hdl.handle.net/11616/93572
dc.identifier.volume49en_US
dc.identifier.wosWOS:000184383900012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofJournal of Tropical Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInfluenza Vaccinationen_US
dc.subjectYoung-Adultsen_US
dc.subjectTuberculosisen_US
dc.subjectMiceen_US
dc.subjectInfectionen_US
dc.titleThe effects of androstenediol and dehydroepiandrosterone on the immune response to BCG at pubertyen_US
dc.typeArticleen_US

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