Reduction of ischemia-reperfusion induced myocardial infarct size in rats by caffeic acid phenethyl ester (CAPE)

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dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.contributor.authorOzer, MK
dc.contributor.authorParlakpinar, H
dc.contributor.authorAcet, A
dc.date.accessioned2024-08-04T20:30:43Z
dc.date.available2024-08-04T20:30:43Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractMyocardial ischemia-reperfusion (MI/R) represents a clinically relevant problem associated with thrombolysis, angioplasty, and coronary bypass surgery. MI/R injury is known to occur on restoration of coronary flow after a period of myocardial ischemia. Injury of myocardium caused by I/R includes cardiac contractile dysfunction, arrhythmias, as well as irreversible myocyte damage. Prevention of myocardial death in acute coronary syndromes is the immediate goal of therapy. The main factor concerned with the experimental generation of reperfusion damage is oxygen-derived free radicals. This MI/R injury has been shown to be salvaged by supplementing antioxidants to diseased hearts. Caffeic acid phenethyl ester (CAPE), an active component of propolis extract, has antioxidant and anti-inflammatory properties, and may function in cardiac protection against I/R-induced damage. To test this hypothesis, we randomly assigned 14 male Wistar rats for necrosis experiments. To produce myocardial necrosis, the left main coronary artery was occluded for 30 min, followed by 120 min of reperfusion in anesthetized rats. CAPE (50 muM kg(-1)) was given intravenously 10 min before occlusion and continued during ischemia by infusion pump. The volume of infarct and the risk zone was determined by planimentry of each tracing and multiplying by the slice thickness. Infarct was normalized by expressing it as a percentage of the area at risk. Compared to control group, CAPE administration statistically reduced the myocardial infarct size/area of risk zone (50 +/- 4% and 32 +/- 6%, respectively) and the myocardial infarct size (23 +/- 3% and 9 +/- 4%, respectively) in rat model of ischemia-reperfusion. In conclusion, this result shows that CAPE is important in reducing I/R-induced myocardial damage. (R) 2004 The Canadian Society of Clinical Chemists. All rights reserved.en_US
dc.identifier.doi10.1016/j.clinbiochem.2004.01.012
dc.identifier.endpage705en_US
dc.identifier.issn0009-9120
dc.identifier.issn1873-2933
dc.identifier.issue8en_US
dc.identifier.pmid15302615en_US
dc.identifier.scopus2-s2.0-4043126719en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage702en_US
dc.identifier.urihttps://doi.org/10.1016/j.clinbiochem.2004.01.012
dc.identifier.urihttps://hdl.handle.net/11616/94479
dc.identifier.volume37en_US
dc.identifier.wosWOS:000223593500010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofClinical Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcaffeic acid phenethyl ester (CAPE)en_US
dc.subjectischemia-reperfusionen_US
dc.subjectinfarct sizeen_US
dc.subjectheart and raten_US
dc.titleReduction of ischemia-reperfusion induced myocardial infarct size in rats by caffeic acid phenethyl ester (CAPE)en_US
dc.typeArticleen_US

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