An attempt to decrease ammonia levels after portacaval anastomosis in dogs - Hepatic periarterial neurectomy

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dc.authoridBasak, Kayhan/0000-0003-1960-8924
dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridKatz, Daniel/0000-0002-6495-0078
dc.authoridKayaalp, Cuneyt/0000-0003-4657-2998
dc.authorwosidKayaalp, Cuneyt/AAH-1764-2021
dc.authorwosidBasak, Kayhan/E-1823-2012
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.contributor.authorYilmaz, S
dc.contributor.authorKirimlioglu, V
dc.contributor.authorKatz, D
dc.contributor.authorBasak, K
dc.contributor.authorCaglikulekci, M
dc.contributor.authorKayaalp, C
dc.contributor.authorYildirim, B
dc.date.accessioned2024-08-04T20:13:09Z
dc.date.available2024-08-04T20:13:09Z
dc.date.issued2002
dc.departmentİnönü Üniversitesien_US
dc.description.abstractHepatic encephalopathy and elevated serum ammonia levels occur commonly after portacaval shunt and are hypothesized to be, in part, due to decreased hepatic blood flow. Prior work has demonstrated increased blood flow to the liver following hepatic periarterial neurectomy. In this experimental study, we investigated the functional, hemodynamic, and histopathological changes in the liver and kidney occurring after the addition of hepatic periarterial neurectomy to side-to-side portacaval shunt in dogs. It is our hypothesis that the addition of hepatic periarterial neurectomy to portacaval shunt will decrease postshunt ammonia levels. Side-to-side portacaval shunt was performed in 12 dogs (group I). Hepatic periarterial neurectomy was added to portacaval shunt in 9 dogs (group II). Serum levels of ammonia, urea, creatinine, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, albumin, and bilirubin together with hepatic blood flow were determined in both groups preoperatively and on postoperative day 21. The pre- and postoperative histopathologic changes of the liver and kidney were evaluated. There was significantly less postoperative elevation of serum ammonia and aspartate aminotransferase when hepatic periarterial neurectomy was added to the portacaval shunt procedure. Hemodynamic studies of hepatic artery and hepatic tissue indicated better blood flow in group II. The histopathologic evaluation of group II showed expansion of sinusoids, portal vessels, and portal areas and increased portal fibrosis as compared to group I. The results of this experimental study show that adding hepatic periarterial neurectomy to the portacaval shunt procedure improves postoperative serum levels of ammonia and aspartate aminotransferase and hepatic artery and tissue blood flow.en_US
dc.identifier.doi10.1023/A:1019635820789
dc.identifier.endpage1952en_US
dc.identifier.issn0163-2116
dc.identifier.issue9en_US
dc.identifier.pmid12353834en_US
dc.identifier.scopus2-s2.0-0036719244en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1943en_US
dc.identifier.urihttps://doi.org/10.1023/A:1019635820789
dc.identifier.urihttps://hdl.handle.net/11616/93433
dc.identifier.volume47en_US
dc.identifier.wosWOS:000177345400008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKluwer Academic/Plenum Publen_US
dc.relation.ispartofDigestive Diseases and Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthepatic encephalopathyen_US
dc.subjectportacaval shunten_US
dc.subjecthepatic periarterial neurectomyen_US
dc.titleAn attempt to decrease ammonia levels after portacaval anastomosis in dogs - Hepatic periarterial neurectomyen_US
dc.typeArticleen_US

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