Melatonin s protective effect on the salivary gland against ionized radiation damage in rats

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dc.authoridTR38600en_US
dc.authoridTR58662en_US
dc.authoridTR45132en_US
dc.authoridTR100549en_US
dc.authoridTR125476en_US
dc.authoridTR102000en_US
dc.contributor.authorÇakmak Karaer, Işıl
dc.contributor.authorŞimşek, Gökçe
dc.contributor.authorYıldız, Azibe
dc.contributor.authorVardı, Nigar
dc.contributor.authorPolat, Alaadin
dc.contributor.authorTanbek, Kevser
dc.contributor.authorGürocak, Simay
dc.contributor.authorParlakpınar, Hakan
dc.date.accessioned2017-04-11T07:37:08Z
dc.date.available2017-04-11T07:37:08Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to examine the effects of melatonin on ionized radiation-induced salivary gland damage using an experimental model. Thirty-two rats were randomized into four groups: (i) the control group (C, n = 8) that received intraperitoneal (i.p.) 0.9% NaCl; (ii) the melatonin group (M, n = 8) that received i.p. 5 mg/kg melatonin; (iii) the radiotherapy group (RT, n = 8) that underwent irradiation; (iv) the melatonin plus radiotherapy group (M+RT, n = 8) that received i.p. 5 mg/kg of melatonin, followed by irradiation 30 min later; and (v) the radiotherapy plus melatonin group (RT+M, n = 8) that received irradiation followed by i.p. 5 mg/kg of melatonin 30 min later. The medications and irradiation were administered for 5 days and the salivary glands of the rats were excised 10 days later; the histopathological changes in the salivary glands were assessed and biochemical analyses were conducted (tissue levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI)). Regardless of whether melatonin was administered before or after radiotherapy, melatonin decreased the radiation-induced parotid and submandibular histological damage. In addition, regardless of whether administration occurred before or after radiotherapy, melatonin decreased oxidative stress markers, such as MDA, TOS, and OSI. On the contrary, levels of antioxidative markers, such as CAT and GPx, were increased by melatonin. Melatonin may have a significant protective effect on salivary gland damage secondary to ionizing radiation.en_US
dc.identifier.citationKaraer Çakçmak, I., Şimşek, G., Yıldız, A., Vardı, N., Polat, A., Tanbek, K. Gürocak, S. Parlakpınar, H. (2016). Melatonin s protective effect on the salivary gland against ionized radiation damage in rats. Journal of Oral Pathology & Medicine, 45(6), 444–449.en_US
dc.identifier.doi10.1111/jop.12386en_US
dc.identifier.endpage449en_US
dc.identifier.issn09042512
dc.identifier.issue6en_US
dc.identifier.startpage444en_US
dc.identifier.urihttp://doi.wiley.com/10.1111/jop.12386
dc.identifier.urihttps://hdl.handle.net/11616/6618
dc.identifier.volume45en_US
dc.language.isoenen_US
dc.publisherJournal of Oral Pathology & Medicineen_US
dc.relation.ispartofJournal of Oral Pathology & Medicineen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMelatoninen_US
dc.subjectOxidative stressen_US
dc.subjectRadiotherapyen_US
dc.subjectSalivary glanden_US
dc.titleMelatonin s protective effect on the salivary gland against ionized radiation damage in ratsen_US
dc.typeArticleen_US

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