Toxic epidermal necrolysis due to concomitant use of valproic asid and lamotrigine

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dc.authoridCenk, Hülya/0000-0003-4871-6342;
dc.authorwosidCenk, Hülya/A-1293-2016
dc.authorwosidOzcan, Hamdi/T-8408-2019
dc.contributor.authorOzcan, Hamdi
dc.contributor.authorCenk, Hulya
dc.contributor.authorCumurcu, Birgul
dc.date.accessioned2024-08-04T20:41:09Z
dc.date.available2024-08-04T20:41:09Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractToxic epidermal necrolysis (TEN) is a rare but life-threatening acute mucacutaneous hypersensitivity reaction, usually related to medications. Concomitant use of lamotrigine and valproic acid can cause this serious reaction. A 36-year-old male was admitted to the emergency department with the complaints of high fever, burning sensation at eyes, oral and genital mucous erosions, generalized rush and weakness. He had been taking valproic asid, olanzapine, and sertraline for bipolar affective disorder. Lamotrigine 25 mg/day treatment was added to his treatment protocol 15 days before the rush and lamotgine dose was increased 50 mg/day 10 days later. The patient was diagnosed with TEN caused by concomitant use of valproic acid and lamotrigine. The patient was followed up and treated at the burn unit with intravenous immunoglobulin, corticosteroid and antibiotics. Concomitant use of valproic acid and lamotrigine increases the frequency of adverse reaction. TEN may cause serious complications and death. Patients with TEN should be followed by a multi-disciplinary team. Early determination of complications and suitable management can increase the odds for survival.en_US
dc.identifier.doi10.4274/turkderm.55481
dc.identifier.endpage172en_US
dc.identifier.issn2717-6398
dc.identifier.issn2651-5164
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84940474119en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage169en_US
dc.identifier.urihttps://doi.org/10.4274/turkderm.55481
dc.identifier.urihttps://hdl.handle.net/11616/96957
dc.identifier.volume49en_US
dc.identifier.wosWOS:000369627900018en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherDeri Zuhrevi Hastaliklar Dernegien_US
dc.relation.ispartofTurkderm-Turkish Archives of Dermatology and Venerologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectToxic epidermal necrolysisen_US
dc.subjectlamotrigineen_US
dc.subjectvalproic aciden_US
dc.titleToxic epidermal necrolysis due to concomitant use of valproic asid and lamotrigineen_US
dc.typeArticleen_US

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