Neopterin Levels and Indoleamine 2,3-Dioxygenase Activity as Biomarkers of Immune System Activation and Childhood Allergic Diseases

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dc.authorid, BAYDAR/0000-0002-5497-9600
dc.authoridÜnüvar, Songül/0000-0001-8454-490X
dc.authoridBAYDAR, Terken/0000-0002-5497-9600
dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authorwosid, BAYDAR/J-1107-2013
dc.authorwosidÜnüvar, Songül/ABH-5516-2020
dc.authorwosidBAYDAR, TERKEN/JAC-5447-2023
dc.authorwosidBAYDAR, Terken/JRY-1626-2023
dc.authorwosidGozukara Bag, Harika Gozde/ABG-7588-2020
dc.contributor.authorUnuvar, Songul
dc.contributor.authorErge, Duygu
dc.contributor.authorKilicarslan, Bilge
dc.contributor.authorBag, Harika Gozde Gozukara
dc.contributor.authorCatal, Ferhat
dc.contributor.authorGirgin, Gozde
dc.contributor.authorBaydar, Terken
dc.date.accessioned2024-08-04T20:45:40Z
dc.date.available2024-08-04T20:45:40Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Although Th2 immune activation is predominant in allergic diseases, neopterinlevels and indoleamine 2,3-dioxygenase (IDO)-1 activity (kynurenine:tryptophan ratio), which reflect Th1 immune activity, increase with interferon-gamma (IFN-gamma) stimulation. We investigated neopterin, tryptophan, and kynurenine levels as biomarkersof the Th1 immune system activation and changes in IDO-1 activityin children with asthma, allergic rhinitis, and atopic dermatitis, as well as the relationship between these biomarkers and the total IgE level, age, and disease severity. Methods: We divided 205 children (80 girls and 125 boys, four months to 17 years old) into four groups: controls, patients with asthma, patients with allergic rhinitis, and patients with atopic dermatitis. Peripheral venous blood samples were collected. Neopterin levels were determined by an enzyme immunoassay. Tryptophan and kynurenine levels were analyzed using HPLC. IDO-1 enzyme activity was calculated using tryptophan and kynurenine levels. IgE levels were measured. The Mann-Whitney U test, Kruskal-Wallis test, and Conover post-hoc method were used for statistical analysis. Results: Neopterin, tryptophan, and kynurenine levels were higher and IgE levels and IDO-1 enzyme activity were lower in patients with asthma and allergic rhinitis than in controls (P<0.05). Patients with atopic dermatitis showed higher neopterin, tryptophan, and kynurenine levels, higher IDO-1 activity, and lower IgE levels thancontrols (P<0.05). Conclusions: The Th1/Th2 balance is disrupted in children with allergic diseases, concomitant with increased Th1-mediated immune response activation and reduced IgEproduction, which is promoted by Th2-type cytokines.en_US
dc.identifier.doi10.3343/alm.2019.39.3.284
dc.identifier.endpage290en_US
dc.identifier.issn2234-3806
dc.identifier.issn2234-3814
dc.identifier.issue3en_US
dc.identifier.pmid30623620en_US
dc.identifier.scopus2-s2.0-85059798173en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage284en_US
dc.identifier.urihttps://doi.org/10.3343/alm.2019.39.3.284
dc.identifier.urihttps://hdl.handle.net/11616/98604
dc.identifier.volume39en_US
dc.identifier.wosWOS:000455506700007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKorean Soc Laboratory Medicineen_US
dc.relation.ispartofAnnals of Laboratory Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAllergyen_US
dc.subjectKynurenineen_US
dc.subjectNeopterinen_US
dc.subjectTryptophanen_US
dc.subjectAtopic dermatitisen_US
dc.subjectAllergic rhinitisen_US
dc.subjectAsthmaen_US
dc.subjectTh1 immune responseen_US
dc.subjectindoleamine 2,3-dioxygenase activityen_US
dc.titleNeopterin Levels and Indoleamine 2,3-Dioxygenase Activity as Biomarkers of Immune System Activation and Childhood Allergic Diseasesen_US
dc.typeArticleen_US

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