Genotoxic effects of tacrolimus on human lymphocyte cells.

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dc.authorscopusid55218229500
dc.authorscopusid12797912000
dc.contributor.authorKurtoglu E.L.
dc.contributor.authorYuksel S.
dc.date.accessioned2024-08-04T19:59:07Z
dc.date.available2024-08-04T19:59:07Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe designed in vitro study to determine possible genotoxic effects oftacrolimus (FK-506), which is used as a potent immunosuppressive drug, by using sister chromatid exchange (SCEs), chromosome aberration (CAs), micronuclei tests (MN) and cell growth kinetics such as mitotic index (MI) and replication index (RI) in human lymphocytes. The cells were treated with 5, 25, 50, and 100 ng/mL concentrations of tacrolimus, for 24 h and 48 h treatment periods. Tacrolimus induced CA and MN frequency at all concentrations for 24 and 48 h In additon, it induced the SCE at the highest concantration for 24 h and at 25 and 100 ng/mL for 48 h. Tacrolimus decreased MI at all concentrations (except 5 ng/mL) for all treatment periods. It also inhibited the RI at 50 and 100 ng/mL concentrations for 24 h and at all concentrations for 48 h. Treatments given with tacrolimus result in the enhance of the different endpoints ofgenotoxicity, suggesting its mutagenic action on lymphocytes in vitro.en_US
dc.identifier.endpage767en_US
dc.identifier.issn0016-6758
dc.identifier.issue6en_US
dc.identifier.pmid22946334en_US
dc.identifier.scopus2-s2.0-84873054876en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage762en_US
dc.identifier.urihttps://hdl.handle.net/11616/90397
dc.identifier.volume48en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofGenetikaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectimmunosuppressive agenten_US
dc.subjecttacrolimusen_US
dc.subjectarticleen_US
dc.subjectcell cultureen_US
dc.subjectchromosome aberrationen_US
dc.subjectDNA replicationen_US
dc.subjectdrug effecten_US
dc.subjecthumanen_US
dc.subjectlymphocyteen_US
dc.subjectmicronucleus testen_US
dc.subjectmitosis indexen_US
dc.subjectsister chromatid exchangeen_US
dc.subjectCells, Cultureden_US
dc.subjectChromosome Aberrationsen_US
dc.subjectDNA Replicationen_US
dc.subjectHumansen_US
dc.subjectImmunosuppressive Agentsen_US
dc.subjectLymphocytesen_US
dc.subjectMicronucleus Testsen_US
dc.subjectMitotic Indexen_US
dc.subjectSister Chromatid Exchangeen_US
dc.subjectTacrolimusen_US
dc.titleGenotoxic effects of tacrolimus on human lymphocyte cells.en_US
dc.typeArticleen_US

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