Effectiveness of MESNA on the success of cholesteatoma surgery

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dc.authoridOzdamar, Osman Ilkay/0000-0001-8020-0659
dc.authoridçiçek, mehmet turan/0000-0002-0997-7729
dc.authoridBayindir, Tuba/0000-0003-4150-5016;
dc.authorwosidOzdamar, Osman Ilkay/R-8209-2019
dc.authorwosidçiçek, mehmet turan/AAC-2468-2020
dc.authorwosidKalcioglu, M. Tayyar/JAC-1515-2023
dc.authorwosidBayindir, Tuba/ABG-9517-2020
dc.authorwosidKALCIOGLU, Mahmut Tayyar/I-5884-2013
dc.contributor.authorKalcioglu, M. Tayyar
dc.contributor.authorCicek, Mehmet T.
dc.contributor.authorBayindir, Tuba
dc.contributor.authorOzdamar, Osman Ilkay
dc.date.accessioned2024-08-04T20:39:40Z
dc.date.available2024-08-04T20:39:40Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractImportance: It is important that chronic otitis media with cholesteatoma be treated successfully in patients to protect them from having repeated surgeries with related surgical co-morbidities and hearing loss. Objective: To evaluate the effectiveness of MESNA usage on the residual cholesteatoma rates of the patients who underwent surgery due to chronic otitis media with cholesteatoma. Design: Retrospective single-institution study of a prospectively collected database. Setting: Tertiary University Hospital. Participants: Nine hundred and thirty-four patients underwent surgery due to chronic otitis media between September 2000 and March 2012 by the same surgeon. One hundred and forty-one cases out of 934 patients were selected who had cholesteatoma for the study. These randomly selected 141 cases were divided into two groups as follows: I. Forty-six cases were applied MESNA (Sodium 2-mercaptoethanesulfonate) intraoperatively, and II. Ninety-five cases were not applied MESNA intraoperatively. The cases that were followed-up at least one year were included in this study. Intervention: MESNA (Ureomitexan, MESNA, Baxter oncology, Germany) was diluted with saline (20% MESNA and 80% saline) that was applied, and then a waiting period of approximately 5 min followed to start to dissect cholesteatoma matrix. Main outcomes and measures: Residual cholesteatoma rates between intraoperative MESNA, a disulfide bond breaking chemical agent, applied and MESNA non-applied cases in the postoperative follow-up period were compared for the success of the surgery. Results: MESNA was used in 46 patients out of 141 cases intraoperatively. Twenty-four of these patients underwent CWD (canal wall down), and twenty-two patients underwent CWU (canal wall up) mastoidectomy. For the other 95 subjects, 56 patients with CW.D and 39 with CWU mastoidectomy, MESNA was not applied. Residual cholesteatoma rates were found to be significantly higher in MESNA non-applied group than MESNA applied group (p <0.05). Residual cholesteatoma rates between CWD and CWU mastoidectomy procedures were not statistically significant (p > 0.05). Conclusions and relevance: MESNA application that breaks disulfide bonds in the structure of the matrix in cholesteatoma surgery may assist the elimination of the disease, and increase surgical success by facilitating the elevation of the epithelium. Thereby, it causes a decrease in the possibility of remaining residual epithelium after surgery, which decreases the need for second-look surgery. (C) 2014 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.amjoto.2014.01.002
dc.identifier.endpage361en_US
dc.identifier.issn0196-0709
dc.identifier.issn1532-818X
dc.identifier.issue3en_US
dc.identifier.pmid24491375en_US
dc.identifier.scopus2-s2.0-84899926764en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage357en_US
dc.identifier.urihttps://doi.org/10.1016/j.amjoto.2014.01.002
dc.identifier.urihttps://hdl.handle.net/11616/96435
dc.identifier.volume35en_US
dc.identifier.wosWOS:000335934100015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofAmerican Journal of Otolaryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCanal Wallen_US
dc.subjectPediatric Cholesteatomaen_US
dc.subjectRecurrenceen_US
dc.subjectChildrenen_US
dc.subjectEaren_US
dc.titleEffectiveness of MESNA on the success of cholesteatoma surgeryen_US
dc.typeArticleen_US

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