The effect of age specific FSH levels on in vitro fertilization-intracytoplasmic sperm injection/embryo transfer outcomes in women with normal ovarian function
Küçük Resim Yok
Tarih
2016
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
OrtadogŸu Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S.
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: The objective of this study is to determine the effect of age specific follicle stimulating hormone (FSH) levels on the number of oocytes, the number of MII oocytes, fertilization, the number of grade 1 embryos and pregnancy rate in vomen with normal ovarian function for in vitro fertilization-intracytoplasmic sperm injection/embryo transfer cycles. Material and Methods: In this study 392 patients data were reviewed retrospectively between 01.01.2010-01.01.2014 at Çukurova University Faculty of Medicine Department of Obstetrics and Gynecology Assisted Reproduction Treatment Centre who used recombinant follicle stimulating hormone for controlled ovarian stimulation than performed in vitro fertilization-intracytoplasmic sperm injection/embryo transfer due to unexplained infertility. Patients were grouped as women of age 33 and lower, 33-37 and 38-41. Each age group were divided into two subgroups; premature ovaraian aging and control group. Subgroups in all age groups were compared in terms of baseline characteristics and in vitro fertilization (IVF) results. Results: In younger age group the total gonadotropin dose used and the duration of induction were detected statistically significantly higher than premature ovarian aging (POA) patients in control patients. (p=0.004, p=0.048) E2 level at hCG administration day, number of oocytes obtained and the number of MII oocytes were lower than the control group in POA patients (p=0,001, p=0.022, p=0.023 respectively). In the 33-37 age range, in the POA group E2 level at hCG administration day, number of oocytes and the number of MII oocytes retrieved was lower than the control group (p<0.0001, p=0.027, p=0.040 respectively). Conclusion: Interperation and consideration of age-specific FSH levels in treatment planning while taking into account the patient's age may contribute to optimize the IVF outcomes in patients undergoing controlled ovarian hyperstimulation. © Copyright 2016 by Türkiye Klinikleri.
Açıklama
Anahtar Kelimeler
Age groups, Embryo transfer, Fertilization in vitro, Follicle stimulating hormone, Sperm injection, intracytoplasmic
Kaynak
Turkiye Klinikleri Jinekoloji Obstetrik
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
26
Sayı
1
