Serum levels of inflammatory markers CRP, ESR and albumin in relation to survival for patients with hepatocellular carcinoma

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dc.authoridALTINTAS, Engin/0000-0003-0796-1456
dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridBalaban, Yasemin Hatice/0000-0002-0901-9192
dc.authoridCarr, Brian/0000-0002-6111-5077
dc.authorwosidALTINTAS, Engin/R-2585-2019
dc.authorwosidGozukara Bag, Harika Gozde/ABG-7588-2020
dc.authorwosidBalaban, Yasemin Hatice/K-4930-2019
dc.authorwosidDELIK, ANIL/HNR-6191-2023
dc.authorwosidkuran, sedef/V-4297-2018
dc.contributor.authorAkkiz, Hikmet
dc.contributor.authorCarr, Brian I.
dc.contributor.authorBag, Harika G.
dc.contributor.authorKaraogullarindan, Umit
dc.contributor.authorYalcin, Kendal
dc.contributor.authorEkin, Nazim
dc.contributor.authorOzakyol, Aysegul
dc.date.accessioned2024-08-04T20:48:50Z
dc.date.available2024-08-04T20:48:50Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction Hepatocellular carcinoma is associated with several chronic inflammatory conditions. It is increasingly understood that the inflammation may be part of the carcinogenic process and prognostically important. Objective To evaluate the serum levels of three inflammation markers in relation to survival in HCC patients. Methods We retrospectively examined the serum levels of CRP, albumin and ESR, both singly and in combination, in relation to patient survival. Results Survival worsened with increase in CRP or ESR or decrease in albumin levels. Combinations of CRP plus albumin or CRP plus ESR were associated with an even greater range of survival (3-fold), together with significant differences in maximum tumor diameter (PVT) and percent of patients with portal vein thrombosis (PVT). The triplet of CRP plus albumin plus ESR was associated with a sevenfold difference in survival, comparing low vs high parameter levels. These significant differences were found in patients with small or large tumors. Conclusions Combinations of CRP with albumin or ESR or all three parameters together significantly related to differences in survival and to differences in MTD and percent PVT, in patients with both small and large size HCCs.en_US
dc.description.sponsorshipNIH [CA 82723]en_US
dc.description.sponsorshipThis work is supported in part by NIH grant CA 82723 (B.I.C)en_US
dc.identifier.doi10.1111/ijcp.13593
dc.identifier.issn1368-5031
dc.identifier.issn1742-1241
dc.identifier.issue2en_US
dc.identifier.pmid32583494en_US
dc.identifier.scopus2-s2.0-85089895498en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/ijcp.13593
dc.identifier.urihttps://hdl.handle.net/11616/99492
dc.identifier.volume75en_US
dc.identifier.wosWOS:000597843400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGlasgow Prognostic Scoreen_US
dc.subjectC-Reactive Proteinen_US
dc.subjectSystemic Inflammationen_US
dc.subjectAlkaline-Phosphataseen_US
dc.subjectMicroenvironmenten_US
dc.subjectResectionen_US
dc.subjectIndexen_US
dc.titleSerum levels of inflammatory markers CRP, ESR and albumin in relation to survival for patients with hepatocellular carcinomaen_US
dc.typeArticleen_US

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