Cardioprotective potential of melatonin, quercetin and resveratrol in an experimental model of diabetes

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dc.authorscopusid57204961320
dc.authorscopusid56040001000
dc.authorscopusid6701663430
dc.authorscopusid7004559930
dc.contributor.authorBostancıeri N.
dc.contributor.authorElbe H.
dc.contributor.authorEşrefoğlu M.
dc.contributor.authorVardı N.
dc.date.accessioned2024-08-04T20:00:45Z
dc.date.available2024-08-04T20:00:45Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOxygen radicals participate in the pathogenesis of heart damage. Diabetes accelerates the formation of reactive oxygen species (ROS). We investigated the effects of the antioxidants, melatonin, quercetin and resveratrol, on cardiomyopathy and apoptosis in rats with streptozotocin (STZ) induced diabetes mellitus (DM). Rats were divided into five groups of seven: control, DM, DM + melatonin, DM + quercetin and DM + resveratrol. All treatments were begun with a single dose of STZ to induce diabetes and experimental treatments were continued daily for 30 days. Morphologic and apoptotic changes were analyzed by histological assessment. The heart tissue of the control group exhibited normal histology, whereas the heart tissue of the DM group exhibited vacuolization, necrosis, congestion, infiltration and myofibril loss. The DM group exhibited significantly increased apoptosis compared to the control group. Differences in anti-apoptotic effects were statistically significant for all three antioxidant treatment groups; the anti-apoptotic effects of quercetin and resveratrol were similar. Melatonin, resveratrol and quercetin exhibited protective effects against diabetic heart damage. © 2021 The Biological Stain Commission.en_US
dc.identifier.doi10.1080/10520295.2021.1918766
dc.identifier.endpage157en_US
dc.identifier.issn1052-0295
dc.identifier.issue2en_US
dc.identifier.pmid33906539en_US
dc.identifier.scopus2-s2.0-85105215789en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage152en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2021.1918766
dc.identifier.urihttps://hdl.handle.net/11616/90955
dc.identifier.volume97en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofBiotechnic and Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCaspase-3en_US
dc.subjectdiabetic cardiomyopathyen_US
dc.subjectmelatoninen_US
dc.subjectquercetinen_US
dc.subjectraten_US
dc.subjectresveratrolen_US
dc.titleCardioprotective potential of melatonin, quercetin and resveratrol in an experimental model of diabetesen_US
dc.typeArticleen_US

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