The Effect of Caffeic Acid Phenethyl Ester (CAPE) Against Cholestatic Liver Injury in Rats

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dc.authoridYILDIZ, Fahrettin/0000-0001-8836-0374
dc.authoridÖzgör, Dinçer/0000-0001-8519-8869
dc.authoridEşrefoğlu, Mukaddes/0000-0003-3380-1480
dc.authoridPolat, Alaadin/0000-0002-6920-3856;
dc.authorwosidYILDIZ, Fahrettin/AAH-3238-2020
dc.authorwosidÖzgör, Dinçer/AAB-3523-2021
dc.authorwosidEşrefoğlu, Mukaddes/JWA-4590-2024
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.authorwosidAl, Behcet/AAG-9222-2020
dc.contributor.authorCoban, Sacid
dc.contributor.authorYildiz, Fahrettin
dc.contributor.authorTerzi, Alpaslan
dc.contributor.authorAl, Behcet
dc.contributor.authorOzgor, Dincer
dc.contributor.authorAra, Cengiz
dc.contributor.authorPolat, Alaattin
dc.date.accessioned2024-08-04T20:32:21Z
dc.date.available2024-08-04T20:32:21Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives. Caffeic acid phenethyl ester (CAPE) has been subjected to considerable investigations that have revealed its antioxidant and anti-inflammatory activities in different conditions. But there is not a previous investigation about its effect on cholestatic liver injury. The aim of this study was to investigate the effect of CAPE in rat liver against cholestatic liver injury induced by bile duct ligation. Methods. Swiss-albino rats were recruited in the study as follows; Group 1 rats subjected to simple laparotomy known as the sham group; Group 2 rats subjected to bile duct ligation (BDL); Group 3 bile duct ligated rats treated with CAPE. The third group received CAPE (10 mu mol/kg) intraperitoneally daily throughout 14 d. Results. Data showed a decrease in gamma glutamyl transferase (GGT), aspartate aminotransferase (AST), and alanine aminotransferase levels (ALT) of the CAPE treated rats, compared with BDL group (P < 0.001, P < 0.01, and P < 0.02, respectively). In the CAPE treated rats, tissue levels of malondialdehyde (MDA) and myeloperoxidase (MPO) were significantly lower than that of the BDL group (P < 0.001). The levels of glutathione (GSH) in CAPE treated rats were significantly higher than that of BDL group (P < 0.001). In CAPE treated group, the levels of interleukin-1alpha (IL-1 alpha) and interleukin-6 (IL-6) were significantly lower than that of BDL group (P < 0.03, P < 0.02, respectively). Administration of CAPE in the rats with biliary obstruction resulted in inhibition of necro-inflammation. Conclusion. These results suggest that treatment of CAPE maintains antioxidant defenses, reduces oxidative liver injury, cytokine damage, and necro-inflammation in bile duct ligated rats. Thus, CAPE seems to be a promising agent for the attenuation of cholestatic liver injury. (C) 2010 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jss.2008.10.023
dc.identifier.endpage679en_US
dc.identifier.issn0022-4804
dc.identifier.issn1095-8673
dc.identifier.issue2en_US
dc.identifier.pmid19535096en_US
dc.identifier.scopus2-s2.0-77949487413en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage674en_US
dc.identifier.urihttps://doi.org/10.1016/j.jss.2008.10.023
dc.identifier.urihttps://hdl.handle.net/11616/95004
dc.identifier.volume159en_US
dc.identifier.wosWOS:000276072000013en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofJournal of Surgical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcaffeic acid phenethyl ester (CAPE)en_US
dc.subjectbile duct ligationen_US
dc.subjectcholestatic liver injuryen_US
dc.titleThe Effect of Caffeic Acid Phenethyl Ester (CAPE) Against Cholestatic Liver Injury in Ratsen_US
dc.typeArticleen_US

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