Differences in platelet aggregometers to study platelet function and coagulation dysregulation in xenotransplantation

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dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridSaglam, Kutay/0000-0002-0919-8370
dc.authoridEkser, Burcin/0000-0003-0741-8007
dc.authorid, Ping/0000-0003-1055-9505
dc.authoridChen, Angela/0000-0001-6716-2088
dc.authoridIsidan, Abdulkadir/0000-0001-6655-1268
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.authorwosidSaglam, Kutay/ACN-1173-2022
dc.authorwosidEkser, Burcin/I-3288-2019
dc.contributor.authorIsidan, Abdulkadir
dc.contributor.authorChen, Angela M.
dc.contributor.authorSaglam, Kutay
dc.contributor.authorYilmaz, Sezai
dc.contributor.authorZhang, Wenjun
dc.contributor.authorLi, Ping
dc.contributor.authorEkser, Burcin
dc.date.accessioned2024-08-04T20:48:55Z
dc.date.available2024-08-04T20:48:55Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractXenotransplantation (ie, cross-species transplantation) using genetically engineered pig organs could be a limitless source to solve the shortage of organs and tissues worldwide. However, despite prolonged survival in preclinical pig-to-nonhuman primate xenotransplantation trials, interspecies coagulation dysregulation remains to be overcome in order to achieve continuous long-term success. Different platelet aggregometry methods have been previously used to study the coagulation dysregulation with wild-type and genetically engineered pig cells, including the impact of possible treatment options. Among these methods, while thromboelastography and rotational thromboelastometry measure the change in viscoelasticity, optical aggregometry measures the change in opacity. Recently, impedance aggregometry has been used to measure changes in platelet aggregation in electrical conductance, providing more information to our understanding of coagulation dysregulation in xenotransplantation compared to previous methods. The present study reviews the merits and differences of the above-mentioned platelet aggregometers in xenotransplantation research.en_US
dc.description.sponsorshipIndiana University Health [VFR-457]; National Center for Advancing Translational Sciences [UL1TR001108]; Lung Biotechnology LLC; United Therapeutics Corporation; Indiana Clinical and Translational Sciences Instituteen_US
dc.description.sponsorshipIndiana University Health, Grant/Award Number: VFR-457-Ekser; National Center for Advancing Translational Sciences, Grant/Award Number: UL1TR001108; Lung Biotechnology LLC; Indiana Clinical and Translational Sciences Institute; United Therapeutics Corporationen_US
dc.identifier.doi10.1111/xen.12645
dc.identifier.issn0908-665X
dc.identifier.issn1399-3089
dc.identifier.issue1en_US
dc.identifier.pmid32945034en_US
dc.identifier.scopus2-s2.0-85090997075en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1111/xen.12645
dc.identifier.urihttps://hdl.handle.net/11616/99541
dc.identifier.volume28en_US
dc.identifier.wosWOS:000570192600001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofXenotransplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectimpedance aggregometryen_US
dc.subjectoptical aggregometryen_US
dc.subjectrotational thromboelastometryen_US
dc.subjectthromboelastographyen_US
dc.subjectxenotransplantationen_US
dc.titleDifferences in platelet aggregometers to study platelet function and coagulation dysregulation in xenotransplantationen_US
dc.typeReview Articleen_US

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