Quercetin prevents 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced testicular damage in rats

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dc.authoridaydin, muhterem/0000-0002-6494-9229
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authorwosidaydin, muhterem/W-4192-2018
dc.authorwosidÖzdemir, İlknur/AAA-6216-2021
dc.authorwosidVardı, Nigar/C-9549-2018
dc.contributor.authorCiftci, O.
dc.contributor.authorAydin, M.
dc.contributor.authorOzdemir, I.
dc.contributor.authorVardi, N.
dc.date.accessioned2024-08-04T20:35:52Z
dc.date.available2024-08-04T20:35:52Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe protective effect of quercetin on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced testicular damage in rats was investigated. Twenty-two rats were equally divided into four groups; first group was kept as control and given corn oil as carrier. In second group, TCDD was orally administered at the dose of 2 mu (kg week)-1 for 60 days. In third group, quercetin was orally administered at the dose of 20 mg (kg day)-1 by gavages, and in fourth group TCDD and quercetin were given together at the same doses. Although TCDD increased the formation of thiobarbituric acid reactive substances (TBARS) significantly, it caused a significant decline in the levels of glutathione (GSH), catalase (CAT), GSH-Px and CuZn-Superoxide Dismutase (CuZn-SOD) in rats. In contrast, quercetin significantly increased the GSH, CAT, GSH-Px and CuZn-SOD levels but decreased the formation of TBARS. In addition, sperm motility, sperm concentration and serum testosterone levels were significantly decreased but abnormal sperm rate and testicular damage were increased with TCDD treatment. However, these effects of TCDD on sperm parameters, histological changes and hormone levels were eliminated by quercetin treatment. Our results show that administration of TCDD induces testicular damage (oxidative stress, testes tissue damage, serum hormone level and sperm parameters), and quercetin prevents TCDD-induced testicular damage in rats. Thus, quercetin may be useful for the prevention and treatment of TCDD-induced testicular damage.en_US
dc.description.sponsorshipIUBAP (Inonu University) [2009/24]en_US
dc.description.sponsorshipWe acknowledge the support of IUBAP (Scientific Research Fund of Inonu University) under Grant 2009/24.en_US
dc.identifier.doi10.1111/j.1439-0272.2010.01126.x
dc.identifier.endpage173en_US
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue3en_US
dc.identifier.pmid21486423en_US
dc.identifier.scopus2-s2.0-84860234754en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage164en_US
dc.identifier.urihttps://doi.org/10.1111/j.1439-0272.2010.01126.x
dc.identifier.urihttps://hdl.handle.net/11616/95639
dc.identifier.volume44en_US
dc.identifier.wosWOS:000303118500005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject2en_US
dc.subject3en_US
dc.subject7en_US
dc.subject8-TCDDen_US
dc.subjectQuercetinen_US
dc.subjecttesticular damageen_US
dc.subjecttestosteroneen_US
dc.titleQuercetin prevents 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced testicular damage in ratsen_US
dc.typeArticleen_US

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