Essential oil chemical composition, antimicrobial, anticancer, and antioxidant effects of Thymus convolutus Klokov in Turkey

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dc.authoridKucukbay, Fatumetuzzehra/0000-0001-7784-4138
dc.contributor.authorYuceturk, Selma Celen
dc.contributor.authorTurkoglu, Sumeyye Aydogan
dc.contributor.authorKockar, Feray
dc.contributor.authorKucukbay, F. Zehra
dc.contributor.authorAzaz, A. Dilek
dc.date.accessioned2024-08-04T20:49:15Z
dc.date.available2024-08-04T20:49:15Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, the chemical composition, antimicrobial, antioxidant, and anticancer effects of Thymus convolutus Klokov oil and its main compound camphor were investigated. The oil was isolated from T. convolutus using hydrodistillation method, analyzed by gas chromatography/mass spectrometry (GC-MS), and 66 compounds were identified. The main component was determined as camphor at 16.6%. The antioxidant properties were identified with the DPPH (2,2'-diphenyl-1-picrylhydrazyl) radical-scavenging method and, 33.39 +/- 0.25% DPPH was scavenging in 1000 mu g/mL of essential oil. The strong antimicrobial activity was observed against Escherichia coli, Enterobacter aerogenes, Proteus vulgaris, and Pseudomonas aeruginosa with MIC values of 125 mu g/mL. Aspergillus flavus was more sensitive (28%) against T. convolutus essential oil than other fungi. The cytotoxic effect of oil was analyzed by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) method. Camphor was effective on human hepatoma cells (Hep3B) at concentrations of 1 mg/mL, 500, 250, and 125 mu g/mL, while essential oil of T. convolutus was found to be effective at concentrations of 250 and 125 mu g/mL. A reduction in cell proliferation was observed in colon carcinoma cells (HT-29) treated with 500 mu g/mLcamphor for 48 h. No statistically significant effect was found in Umbilical Vein Endothelial Cells (HUVEC) treated with essential oil and camphor.en_US
dc.description.sponsorshipBalikesir University Research Fund [2009/22]en_US
dc.description.sponsorshipThis study was funded by Balikesir University Research Fund (Project No: 2009/22).en_US
dc.identifier.doi10.1515/znc-2020-0070
dc.identifier.endpage203en_US
dc.identifier.issn0939-5075
dc.identifier.issn1865-7125
dc.identifier.issue5-6en_US
dc.identifier.pmid33909957en_US
dc.identifier.scopus2-s2.0-85100038722en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage193en_US
dc.identifier.urihttps://doi.org/10.1515/znc-2020-0070
dc.identifier.urihttps://hdl.handle.net/11616/99739
dc.identifier.volume76en_US
dc.identifier.wosWOS:000645132400003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofZeitschrift Fur Naturforschung Section C-A Journal of Biosciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantimicrobialen_US
dc.subjectantioxidanten_US
dc.subjectcanceren_US
dc.subjectessential oilen_US
dc.subjectThymus convolutus Klokoven_US
dc.titleEssential oil chemical composition, antimicrobial, anticancer, and antioxidant effects of Thymus convolutus Klokov in Turkeyen_US
dc.typeArticleen_US

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