Association between cytokines in induced sputum and severity of chronic obstructive pulmonary disease

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dc.authoridbay karabulut, aysun/0000-0002-7873-2805
dc.authoridMutlu, Levent Cem/0000-0002-3535-5704
dc.authoridHacievliyagil, Suleyman Savas/0000-0002-2572-1870
dc.authoridGunen, Hakan/0000-0001-6631-4457
dc.authorwosidbay karabulut, aysun/HJP-0995-2023
dc.authorwosidMutlu, Levent Cem/HII-6048-2022
dc.authorwosidMutlu, Levent Cem/AAZ-5186-2020
dc.authorwosidHacievliyagil, Suleyman Savas/ABI-7307-2020
dc.authorwosidGunen, Hakan/HKV-9202-2023
dc.contributor.authorHacievliyagil, SS
dc.contributor.authorGunen, H
dc.contributor.authorMutlu, LC
dc.contributor.authorKarabulut, AB
dc.contributor.authorTemel, I
dc.date.accessioned2024-08-04T20:15:23Z
dc.date.available2024-08-04T20:15:23Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractCytokines are known to be increased in induced sputum in chronic obstructive pulmonary disease (COPD). In this study, the relationship between the levels of interleukin-6 (IL-6), interleukin-8 (IL-8), and tumour necrosis factor-alpha (TNF-alpha) in induced sputum of patients with exacerbation of COPD, and the severity of the disease, pulmonary function tests (PFT), arterial blood gases (ABG) were studied. Twenty-four patients with exacerbation of COPD were included in the study. The patients were grouped according to their PFT into two as: Group 1 (FEV, below 50% of the predicted value, severe-very severe COPD, n = 12) and, Group 2 (FEV, above 50% of the predicted value, mild-moderate COPD, n = 12). The levels of IL-6, IL-8 and TNF-alpha in induced sputum of the subjects were measured. The mean levels of IL-6, IL-8 and TNF-alpha in induced sputum were found to be higher in Group 1 (severe-very severe COPD) than in Group 2 (mild-moderate COPD). The differences in IL-6 and IL-8 levels between groups were statistically significant (P < 0.05). A significant correlation was observed between the IL-6 value and FEV1 (r = -0.435, P = 0.034), FEV1/FVC (r = -0.446, P = 0.029), PaO2 (r = -0.711, P = 0.000), SaO(2) (r = -0.444, P = 0.030) and disease duration (r = 0.427, P = 0.037), respectively. Also, the level of IL-8 in induced sputum was inversely correlated with FEV1 (r = -0.562, P = 0.004), PaO2 (r = -0.540, P = 0.006) and SaO(2) (r = -0.435, P = 0.034). However, all three cytokines were positively correlated with the smoking load (r = 0.653, P = 0.001; r = 0.439, P = 0.032; r = 0.649, P = 0.001). We conclude, therefore, that in exacerbated COPD cases with greater degrees of obstruction of the airways have higher levels of cytokines in induced sputum. This can be interpreted to mean that these cytokines are related to the clinical parameters like the ABG and PFT and seem to be the determinant of the severity of the disease. (c) 2005 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.rmed.2005.08.022
dc.identifier.endpage854en_US
dc.identifier.issn0954-6111
dc.identifier.issn1532-3064
dc.identifier.issue5en_US
dc.identifier.pmid16214322en_US
dc.identifier.scopus2-s2.0-33645885891en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage846en_US
dc.identifier.urihttps://doi.org/10.1016/j.rmed.2005.08.022
dc.identifier.urihttps://hdl.handle.net/11616/94358
dc.identifier.volume100en_US
dc.identifier.wosWOS:000237093500011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co Ltden_US
dc.relation.ispartofRespiratory Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOPDen_US
dc.subjectexacerbationen_US
dc.subjectinduced sputumen_US
dc.subjectIL-6en_US
dc.subjectIL-8en_US
dc.subjectTNF-alphaen_US
dc.titleAssociation between cytokines in induced sputum and severity of chronic obstructive pulmonary diseaseen_US
dc.typeArticleen_US

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