Protective effects of buloxibutid and empagliflozin on hypertension-induced cardiac and vascular injury in rats

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dc.contributor.authorOzhan, Onural
dc.contributor.authorColak, Mehmet
dc.contributor.authorKaraca, Elif
dc.contributor.authorDogru, Feyzi
dc.contributor.authorKucukakcali, Zeynep
dc.contributor.authorAcet, Ahmet
dc.contributor.authorParlakpinar, Hakan
dc.date.accessioned2026-04-04T13:37:28Z
dc.date.available2026-04-04T13:37:28Z
dc.date.issued2026
dc.departmentİnönü Üniversitesi
dc.description.abstractThis study aims to see the individual and combined effects of Angiotensin II type 2 (AT2) receptor agonist buloxibutid (also known as Compound 21 or C21) and sodium-glucose co-transporter-2 (SGLT-2) inhibitor empagliflozin (EMPA) on effects of hypertension (HT), which is common today, on the heart, and vascular tissue. Male rats of the Sprague Dawley were divided into 5 groups: Control (C) group, HT group, HT + C21 group, HT + EMPA group and HT + C21 + EMPA group. After the protocol was completed, hemodynamic measurements were taken and heart and aorta tissues were evaluated biochemically, histopatologically and immunohistochemically. When the mean blood pressure (BP) values were compared, the mean BP of the HT group increased significantly compared to the C group (p < 0.05). Superoxide dismutase, glutathione and glutathione peroxidase activities in the heart, glutathione and catalase activities in the descending aorta were significantly higher in all treated groups compared to the HT group (p < 0.05). In the HT + C21 + EMPA group, histopathological damage score in hematoxylin-eosin (HE) stained heart sections compared to the HT group showed a decrease in tissue damage but cell infiltration was still observed. When HE staining method was applied, it was determined that the thoracic aorta sections in group C had normal histologic structure. In the HT group, dilatation in some parts and irregularities in elastic lamellae were observed. It was observed that the treated groups were similar to group C. When considering the individual and combined effects of C21 and EMPA, positive results on heart and vascular tissue were observed by hemodynamic, biochemical and histopathological analyses.
dc.description.sponsorshipInn niversitesi [TYL-2022-3087]
dc.description.sponsorshipI would like to thank Inonu University Scientific Research Projects Unit for providing financial support for with the project code TYL-2022-3087.
dc.identifier.doi10.1007/s10735-025-10708-9
dc.identifier.issn1567-2379
dc.identifier.issn1567-2387
dc.identifier.issue1
dc.identifier.orcid0000-0001-9497-3468
dc.identifier.orcid0000-0001-7956-9272
dc.identifier.orcid0000-0002-7949-9582
dc.identifier.orcid0000-0001-9018-7849
dc.identifier.pmid41513845
dc.identifier.scopus2-s2.0-105027074455
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s10735-025-10708-9
dc.identifier.urihttps://hdl.handle.net/11616/109852
dc.identifier.volume57
dc.identifier.wosWOS:001658898300006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofJournal of Molecular Histology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectAorta
dc.subjectBuloxibutid
dc.subjectEmpagliflozin
dc.subjectHeart
dc.subjectHypertension
dc.titleProtective effects of buloxibutid and empagliflozin on hypertension-induced cardiac and vascular injury in rats
dc.typeArticle

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