Evaluation of emm gene types toxin gene profiles and clonal relatedness of group A streptococci
Yükleniyor...
Dosyalar
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Bosnian Journal of Basic Medical Sciences
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Th e aim of this study is to evaluate antibiotic susceptibilities, emm gene types, toxin gene profi les and clonal relatedness of group A streptococci
(GAS) isolates obtained from patients and carriers. A total of clinical isolates from patients and isolates from carriers were included
in the study. Emm typing, toxin gene detection for speA, speB, speC, speG and smeZ genes and pulsed-fi eld gel electrophoresis (PFGE) was performed.
Twenty-one distinct emm types were detected; the most common types were emm, emm, emm, emm, emm and emm. Th e
detection rates of both emm types and the toxin genes didn’t diff er signifi cantly between patients and carriers. Th e presence of speA and smeZ
was signifi cantly higher in emm and speG was signifi cantly lower in emm when compared to the other emm types. Th e rate of clustering
obtained with PFGE wasn’t signifi cantly diff erent in patients and carriers. As a result, twelve of the emm types detected in this study were
covered by the -valent vaccine, constituting . of the emm typeable isolates; however the emm type which is one of the most common
types in the present study is not among this coverage.
Açıklama
Anahtar Kelimeler
Group A streptococci, Emm typing, Toxin genes, SpeA, SpeB, SpeC, Clonal relation, PFGE
Kaynak
Bosnian Journal of Basic Medical Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
13
Sayı
3
Künye
Mengeloğlu, F. Z. Aktaş, E. Otlu, B. Cömert, F. Külah, C. Taş, E. Sümbüloğlu, V. (2013). Evaluation of emm gene types toxin gene profiles and clonal relatedness of group A streptococci. Bosnian Journal of Basic Medical Sciences. 13 (3); 163-169.
