?-Cryptoxanthin ameliorates metabolic risk factors by regulating NF-?B and Nrf2 pathways in insulin resistance induced by high-fat diet in rodents

Basit Öğe Kaydı
dc.authoridSahin, Kazim/0000-0001-9542-5244
dc.authoridsahin, nurhan/0000-0001-9487-1154
dc.authoridAkdemir, Fatih/0000-0002-5779-6631
dc.authoridOrhan, Cemal/0000-0003-4138-7689
dc.authoridTuzcu, Mehmet/0000-0002-1329-3143
dc.authorwosidSahin, Kazim/D-5625-2009
dc.authorwosidsahin, nurhan/ABF-8007-2020
dc.authorwosidAkdemir, Fatih/AAG-8010-2019
dc.authorwosidSahin, Nurhan/D-5626-2009
dc.authorwosidOrhan, Cemal/Q-2086-2015
dc.authorwosidTuzcu, Mehmet/H-2953-2018
dc.contributor.authorSahin, Kazim
dc.contributor.authorOrhan, Cemal
dc.contributor.authorAkdemir, Fatih
dc.contributor.authorTuzcu, Mehmet
dc.contributor.authorSahin, Nurhan
dc.contributor.authorYilmaz, Ismet
dc.contributor.authorJuturu, Vijaya
dc.date.accessioned2024-08-04T20:43:15Z
dc.date.available2024-08-04T20:43:15Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this experiment was to determine the effects of beta-cryptoxanthin (BCX) on the cardiometabolic health risk factors and NF-kappa B and Nrf2 pathway in insulin resistance induced by high-fat diet (HFD) in rodents. Twenty-eight Sprague-Dawley rats were allocated into four groups: (1) Control, rats fed a standard diet for 12 weeks; (2) BCX, rats fed a standard diet and supplemented with BCX (2.5 mg/kg BW) for 12 weeks; (3) HFD, rats fed a HFD for 12 weeks, (4) HFD + BCX, rats fed a HFD and supplemented with BCX for 12 weeks. BCX reduced cardio-metabolic health markers and decreased inflammatory markers (P < 0.001). Rats fed a HFD had the lower total antioxidant capacity and antioxidant enzymes activities and higher MDA concentration than control rats (P < 0.001 for all). Comparing with the HFD group, BCX in combination with HFD inhibited liver NF-kappa B and TNF-alpha expression by 22% and 14% and enhanced liver Nrf2, HO-1, PPAR-alpha, and p-IRS-1 by 1.43,1.41, 3.53, and 1.33 fold, respectively (P < 0.001). Furthermore, in adipose tissue, BCX up-regulated Nrf2, HO-1, PPAR-alpha, and p-IRS-1 expression, whereas, down-regulated NF-kappa B and TNF-alpha expression. In conclusion, BCX decreased visceral fat and cardiometabolic health risk factors through modulating expressions of nuclear transcription factors. (C) 2017 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipOmniActive Health Technologies Inc. (NJ, USA); Turkish Academy of Sciencesen_US
dc.description.sponsorshipThis study was sponsored by OmniActive Health Technologies Inc. (NJ, USA). This work was also supported in part by the Turkish Academy of Sciences.en_US
dc.identifier.doi10.1016/j.fct.2017.07.008
dc.identifier.endpage279en_US
dc.identifier.issn0278-6915
dc.identifier.issn1873-6351
dc.identifier.pmid28689061en_US
dc.identifier.scopus2-s2.0-85021888593en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage270en_US
dc.identifier.urihttps://doi.org/10.1016/j.fct.2017.07.008
dc.identifier.urihttps://hdl.handle.net/11616/97882
dc.identifier.volume107en_US
dc.identifier.wosWOS:000407982900027en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofFood and Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHigh-fat dieten_US
dc.subjectbeta-cryptoxanthinen_US
dc.subjectInflammationen_US
dc.subjectAntioxidant propertiesen_US
dc.title?-Cryptoxanthin ameliorates metabolic risk factors by regulating NF-?B and Nrf2 pathways in insulin resistance induced by high-fat diet in rodentsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu