Effects of misoprostol on lipoprotein (a) levels of ovariectomized rats

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dc.contributor.authorSonmez, AS
dc.contributor.authorBirincioglu, M
dc.contributor.authorTurkoz, Y
dc.contributor.authorAdam, B
dc.contributor.authorLurie, D
dc.contributor.authorChuong, CJ
dc.date.accessioned2024-08-04T20:12:03Z
dc.date.available2024-08-04T20:12:03Z
dc.date.issued1999
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: To determine the effects of misoprostol on plasma lipoprotein (a) concentrations of ovariectomized rats. Design: Controlled prospective study. Setting: Animal research laboratory. Animal(s): Four-month-old female Sprague-Dawley rats. Intervention(s): Blood samples were obtained before and 60 days after ovariectomy, and the rats were divided into three groups. Group I (five rats) was treated with vehicle (water); groups II and III (nine and eight rats, respectively) were treated with oral misoprostol at 100 and 200 mu g/kg/d, respectively, for 60 days, after which blood was drawn again. Main Outcome Measure(s): Serum lipoprotein (a) levels. Result(s): The median lipoprotein (a) level before ovariectomy was 10.8 mg/dL (range, 10.6-46.5 mg/dL). Sixty days after ovariectomy, the level increased significantly to 15.9 mg/dL (range, 10.6-36.9 mg/dL). After treatment, there was no change in lipoprotein (a) levels in the vehicle-treated group (range, 16.3-21.1 mg/dL); however, the lipoprotein (a) levels decreased significantly in the group treated with 100 mu g/kg/d of misoprostol, from 15.4 mg/dL to 10.8 mg/dL, and in the group treated with 200 mu g/kg/d of misoprostol, from 17.1 mg/dL to 10.6 mg/dL. Conclusion(s): Misoprostol caused a significant decrease in lipoprotein (a) levels. (Fertil Steril(R) 1999;72: 518-21. (C) 1999 by American Society for Reproductive Medicine.) 518.en_US
dc.identifier.doi10.1016/S0015-0282(99)00286-1
dc.identifier.endpage521en_US
dc.identifier.issn0015-0282
dc.identifier.issue3en_US
dc.identifier.pmid10519627en_US
dc.identifier.scopus2-s2.0-0033200088en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage518en_US
dc.identifier.urihttps://doi.org/10.1016/S0015-0282(99)00286-1
dc.identifier.urihttps://hdl.handle.net/11616/93184
dc.identifier.volume72en_US
dc.identifier.wosWOS:000082365600023en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofFertility and Sterilityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectmisoprostolen_US
dc.subjectlipoprotein (a)en_US
dc.subjectovariectomized raten_US
dc.titleEffects of misoprostol on lipoprotein (a) levels of ovariectomized ratsen_US
dc.typeArticleen_US

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