Comparison of the effects of amlodipine and verapamil on autonomic activity in hypertensive patients

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dc.authorscopusid57535532500
dc.authorscopusid6701614367
dc.authorscopusid55958230700
dc.authorscopusid19835359800
dc.contributor.authorSahin I.
dc.contributor.authorKosar F.
dc.contributor.authorAltunkan S.
dc.contributor.authorGünaydin M.
dc.date.accessioned2024-08-04T19:59:37Z
dc.date.available2024-08-04T19:59:37Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Many studies have shown that autonomic activation is one of the major factors in the etiology of hypertension. Furthermore, sympathovagal imbalance may be responsible for arrhythmias and sudden cardiac death. The aim of the present study was to compare and to evaluate the effects of short-term therapy with amlodipine and verapamil on heart rate variability (HRV) in patients with essential hypertension. Methods: Forty patients with essential hypertension (11 men and 29 women, mean age 50.5±10.4 years) were included in the study. Patients with cardiac, metabolic, or any other systemic disease were excluded. Patients were randomized to receive either amlodipine (10 mg; n=20) or verapamil (240 mg; n=20). Patients underwent 24-h Holter monitoring assessment before treatment and after the 4-week treatment period. Standard deviation of normal RR intervals (SDNN), standard deviation of all 5-min mean normal RR intervals (SDANN), square root of the mean of the sum of the squares of differences between adjacent RR intervals (r-MSSD), and pNN50 (time domain variables) and TF, high-frequency power (HF), low-frequency power (LF), and sympathovagal balance (LF/HF; frequency domain variables) were analyzed before and after treatment. Results: Blood pressure (BP) was reduced to a similar degree, from 182/104 to 128/85 mmHg with verapamil and from 174/100 to 124/86 mmHg with amlodipine (verapamil p<0.001; amlodipine p<0.001). This study revealed that amlodipine had no significant effect on any of the time or frequency domain parameters. In contrast, in patients on verapamil, there were significant increases in all time domain parameters, and the LF/HF ratio was significantly decreased (p<0.05). Conclusions: These results suggest that verapamil may have additional positive effects on sympathico-parasympathetic control beyond lowering blood pressure compared with amlodipine, even after short-term treatment in hypertensive patients. © 2004 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.ejim.2004.04.005
dc.identifier.endpage230en_US
dc.identifier.issn0953-6205
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-3543054674en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage225en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejim.2004.04.005
dc.identifier.urihttps://hdl.handle.net/11616/90747
dc.identifier.volume15en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofEuropean Journal of Internal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmlodipineen_US
dc.subjectHeart rate variabilityen_US
dc.subjectVerapamilen_US
dc.titleComparison of the effects of amlodipine and verapamil on autonomic activity in hypertensive patientsen_US
dc.typeArticleen_US

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