Interferon-alpha reduces the development of experimental necrotizing enterocolitis

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dc.authoridDemircan, Mehmet/0000-0002-4022-1276
dc.authoridbay karabulut, aysun/0000-0002-7873-2805
dc.authoridUĞURALP, SEMA/0000-0002-7628-0550
dc.authorwosidGürbüz, Necla/H-8965-2018
dc.authorwosidDemircan, Mehmet/B-1904-2008
dc.authorwosidbay karabulut, aysun/HJP-0995-2023
dc.authorwosidDemircan, Mehmet/AAW-7162-2020
dc.authorwosidUĞURALP, SEMA/ABH-6309-2020
dc.contributor.authorUguralp, S
dc.contributor.authorMizrak, B
dc.contributor.authorKarabulut, AB
dc.contributor.authorGürbüz, N
dc.contributor.authorDemircan, M
dc.date.accessioned2024-08-04T20:13:42Z
dc.date.available2024-08-04T20:13:42Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractCytokines had important role in the pathogenesis of necrotizing enterocolitis (NEC). The aim of this study is to investigate if IFN-alpha has a prophylaxic, effect on experimental NEC development in newborn rat pups. Twenty eight Wistar Albino newborn rat pups were divided into three groups. Control group rats were breast-fed, NEC group and interferon (IFN) group rat pups were hand-fed with premature newborn formula. IFN-alpha was administered subcutaneously at a dose of 50,000 IU/rat/day in IFN group. NEC was induced experimentally by cold stress twice a day in IFN and NEC groups. On the fourth day, the rats were killed, and all the intestine were removed to determine the tissue level of malonaldehyde (MDA) and histologic changes. The microscopic lesions in the NEC group rats were virtually the same as those seen in neonatal NEC, with severe separation of submucosa and/or lamina propria, loss of villi and in some cases necrosis to extention the muscularis. In contrast, in the rats treated with IFN, lesions were moderate separation of submucosa and/or lamina propria, edema in submucosal and muscular layers. Intestinal injury score and MDA levels in NEC group were significantly higher than in the IFN group (P < 0.05). In conclusion it was suggested that IFN-a was effective in reducing the severity of NEC in rat pups. (C) 2004 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.cyto.2003.11.001
dc.identifier.endpage211en_US
dc.identifier.issn1043-4666
dc.identifier.issn1096-0023
dc.identifier.issue5en_US
dc.identifier.pmid15036246en_US
dc.identifier.scopus2-s2.0-1242340405en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage204en_US
dc.identifier.urihttps://doi.org/10.1016/j.cyto.2003.11.001
dc.identifier.urihttps://hdl.handle.net/11616/93794
dc.identifier.volume25en_US
dc.identifier.wosWOS:000220222500002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Ltd- Elsevier Science Ltden_US
dc.relation.ispartofCytokineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectnecrotizing enterocolitisen_US
dc.subjectinterferonen_US
dc.subjectintestineen_US
dc.subjectintestinal immune functionen_US
dc.subjectcytokineen_US
dc.titleInterferon-alpha reduces the development of experimental necrotizing enterocolitisen_US
dc.typeArticleen_US

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