The indices of endogenous oxidative and antioxidative processes in plasma from schizophrenic patients The possible role of oxidant/antioxidant imbalance

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dc.authoridUnal, Suheyla/0000-0003-3266-6256
dc.authoridUnal, Suheyla/0000-0003-3266-6256;
dc.authorwosidUnal, Suheyla/AAS-2388-2020
dc.authorwosidUnal, Suheyla/JVO-8367-2024
dc.authorwosidFadillioglu, Ersin/K-3817-2019
dc.authorwosidUnal, Suheyla/HJH-7559-2023
dc.authorwosidUz, Efkan/B-2943-2016
dc.contributor.authorAkyol, Ö
dc.contributor.authorHerken, H
dc.contributor.authorUz, E
dc.contributor.authorFadillioglu, E
dc.contributor.authorÜnal, S
dc.contributor.authorSögüt, S
dc.contributor.authorÖzyurt, H
dc.date.accessioned2024-08-04T20:13:09Z
dc.date.available2024-08-04T20:13:09Z
dc.date.issued2002
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThere is great evidence in recent years that oxygen free radicals play an important role in the pathophysiology of schizophrenia. The present study was performed to assess the changes in plasma nitric oxide (NO) and thiobarbituric acid-reactive substances (TBARS) levels, and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and xanthine oxidase (XO) activities in schizophrenic patients compared to age- and sex-matched normal controls. A hundred patients with schizophrenia and 51 healthy volunteers were included in the study. XO, SOD, and GSH-Px activities as well as NO and TBARS levels were estimated by standard biochemical techniques in the plasma of normal healthy controls and schizophrenia patients. In schizophrenia, increased plasma XO activity (P<.0001) and NO levels (P<.0001), decreased SOD activity (P<.0001), and unchanged GSH-Px activity were detected compared to control group. Plasma TBARS levels were increased in schizophrenic patients (P<.01), especially in the residual subtype. TBARS levels in nonsmoker schizophrenic patients were found to be higher than nonsmoker controls. Although TBARS levels in both patients and controls were found to be higher in smokers as compared to nonsmokers, it was not statistically significant. No effects of duration of the illness, gender, and low and high dose of daily neuroleptic treatment equivalent to chlorpromazine on oxidant and antioxidant parameters were observed. Because the dose and the duration of treatment with drugs have no influence on the results, it can be interpreted that the findings are more likely to be related mainly to the underlying disease. These findings indicated a possible role of increased oxidative stress and diminished enzymatic antioxidants, both of which may be relevant to the pathophysiology of schizophrenia. On the other hand, increased NO production by nitric oxide synthetases (NOSs) suggests a possible role of NO in the pathophysiological process of schizophrenia. These findings may also suggest some clues for the new treatment strategies with antioxidants and NO synthase (NOS) inhibitors in schizophrenia. (C) 2002 Elsevier Science Inc. All rights reserved.en_US
dc.identifier.doi10.1016/S0278-5846(02)00220-8
dc.identifier.endpage1005en_US
dc.identifier.issn0278-5846
dc.identifier.issn1878-4216
dc.identifier.issue5en_US
dc.identifier.pmid12369276en_US
dc.identifier.scopus2-s2.0-0036592438en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage995en_US
dc.identifier.urihttps://doi.org/10.1016/S0278-5846(02)00220-8
dc.identifier.urihttps://hdl.handle.net/11616/93423
dc.identifier.volume26en_US
dc.identifier.wosWOS:000178043300025en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofProgress in Neuro-Psychopharmacology & Biological Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectglutathione peroxidase (GSH-Px)en_US
dc.subjectnitric oxide (NO)en_US
dc.subjectschizophreniaen_US
dc.subjectsuperoxide dismutase (SOD)en_US
dc.subjectthiobarbituric acid-reactive substances (TBARS)en_US
dc.subjectxanthine oxidase (XO)en_US
dc.titleThe indices of endogenous oxidative and antioxidative processes in plasma from schizophrenic patients The possible role of oxidant/antioxidant imbalanceen_US
dc.typeReview Articleen_US

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