Diagnostic approach of tuberculous lymphadenitis in a multicenter study

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dc.authoridAltunal, Lütfiye Nilsun/0000-0003-4794-9283
dc.authoridKose, Adem/0000-0002-1853-1243
dc.authoridEmre, Salih/0000-0003-4216-5287
dc.authoridGezer, Yakup/0000-0002-1582-7313
dc.authorwosidAltunal, Lütfiye Nilsun/ABF-4899-2022
dc.authorwosidKose, Adem/AAD-1226-2020
dc.authorwosidEmre, Salih/HGC-3199-2022
dc.contributor.authorYenilmez, Ercan
dc.contributor.authorOzakinsel, Duygu
dc.contributor.authorKose, Adem
dc.contributor.authorOlcar, Yildiz
dc.contributor.authorDuman, Zehra
dc.contributor.authorCeylan, Mehmet R.
dc.contributor.authorBozkurt, Fatma
dc.date.accessioned2024-08-04T20:56:05Z
dc.date.available2024-08-04T20:56:05Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: Tuberculous lymphadenitis (TBLN) is the most common infectious etiology of peripheral lymphadenopathy in adults, in Turkiye. This study aimed to identify the demographic, clinical, and laboratory variables that differentiate TBLN from non-tuberculous lymphadenitis (NTBLN), as well as the etiology of lymphadenopathy in adults. Methodology: Patients who were over 18 years old and were referred to the infectious disease outpatient clinics with complaints of swollen peripheral lymph nodes, and who underwent lymph node biopsy between 1 January 2010 and 1 March 2021, were included in this multicenter, nested case-control study. Results: A total of 812 patients at 17 tertiary teaching and research hospitals in Turkiye were included in the study. TBLN was the most frequent diagnosis (53.69%). The proportion of patients diagnosed with TBLN was higher among females; and among those who had a higher erythrocyte sedimentation rate, positive purified protein derivative test, and positive interferon -gamma release test result ( p < 0.05). However, TBLN was less frequent among patients with generalized lymphadenopathy, bilateral lymphadenopathy, axillary lymphadenopathy, inguinal lymphadenopathy, hepatomegaly, splenomegaly, leukocytosis, and moderately increased C reactive protein levels ( p < 0.05). Conclusions: Identifying the variables that predict TBLN or discriminate TBLN from NTBLN will help clinicians establish optimal clinical strategies for the diagnosis of adult lymphadenopathy.en_US
dc.identifier.doi10.3855/jidc.19502
dc.identifier.endpage750en_US
dc.identifier.issn1972-2680
dc.identifier.issue5en_US
dc.identifier.pmid38865395en_US
dc.identifier.scopus2-s2.0-85195861479en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage742en_US
dc.identifier.urihttps://doi.org/10.3855/jidc.19502
dc.identifier.urihttps://hdl.handle.net/11616/102051
dc.identifier.volume18en_US
dc.identifier.wosWOS:001247147800013en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJ Infection Developing Countriesen_US
dc.relation.ispartofJournal of Infection in Developing Countriesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectlymphadenopathyen_US
dc.subjecttuberculous lymphadenitisen_US
dc.subjectlymph node biopsyen_US
dc.subjectadulten_US
dc.subjectetiologyen_US
dc.subjectTurkeyen_US
dc.titleDiagnostic approach of tuberculous lymphadenitis in a multicenter studyen_US
dc.typeArticleen_US

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