Antioxidative effects of curcumin, ?-myrcene and 1,8-cineole against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced oxidative stress in rats liver

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dc.authoridOguzturk, Hakan/0000-0002-9800-1428
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authoridTANYILDIZI, SADETTIN/0000-0001-7012-5392
dc.authorwosidÖzdemir, İlknur/AAA-6216-2021
dc.authorwosidOguzturk, Hakan/AAC-3915-2021
dc.authorwosidYILDIZ, SEDAT/AAB-6354-2021
dc.authorwosidoguzturk, hakan/Q-6242-2019
dc.contributor.authorCiftci, Osman
dc.contributor.authorOzdemir, Ilknur
dc.contributor.authorTanyildizi, Sadettin
dc.contributor.authorYildiz, Sedat
dc.contributor.authorOguzturk, Hakan
dc.date.accessioned2024-08-04T20:32:50Z
dc.date.available2024-08-04T20:32:50Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the effectiveness of curcumin, beta-myrcene (myrcene) and 1,8-cineole (cineole) on antioxidant defense system in rats given a persistent environmental pollutant (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD). Rats (n = 112) were divided randomly into 8 equal groups. One group was kept as control and given corn oil as carrier. TCDD was orally administered at the dose of 2 mu g/kg/week. Curcumin, myrcene and cineole were orally administered at the doses of 100 mg/kg/day, 200 mg/kg/day and 100 mg/kg/day, respectively, by gavages dissolved in corn oil with and without TCDD. The liver samples were taken from half of all rats on day 30 and from the remaining half on day 60 for the determination of thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH), catalase (CAT), glutathione peroxidase (GSH-Px) and CuZn-SOD levels by spectrophotometric method. The results indicated that although TCDD significantly (p <= 0.01) increased formation of TBARS, it caused a significant decline in the levels of GSH, CAT, GSH-Px and CuZn-SOD in rats. In contrast, curcumin, myrcene and cineole significantly increased GSH, CAT, GSH-Px and CuZn-SOD levels but decreased formation of TBARS. Additionally, the antioxidative effects of curcumin, myrcene and cineole were increased at day 60 compared to day 30. In the TCDD groups given curcumin, myrcene and cineole, oxidative stress decreased by time. In conclusion, curcumin, myrcene and cineole showed antioxidant activity and eliminated TCDD-induced oxidative stress in rats in a time-dependent manner.en_US
dc.description.sponsorshipScientific and Technical Research Council of the Turkish Republic (TUBITAK) [106O815]; Inonu University (IUBAP) [2009/24]en_US
dc.description.sponsorshipThis study was supported by Scientific and Technical Research Council of the Turkish Republic (TUBITAK) and Scientific Research Fund of Inonu University (IUBAP) under Grant 106O815, 2009/24, respectively.en_US
dc.identifier.doi10.1177/0748233710388452
dc.identifier.endpage453en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue5en_US
dc.identifier.pmid21245202en_US
dc.identifier.scopus2-s2.0-79957631884en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage447en_US
dc.identifier.urihttps://doi.org/10.1177/0748233710388452
dc.identifier.urihttps://hdl.handle.net/11616/95337
dc.identifier.volume27en_US
dc.identifier.wosWOS:000291038300007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology and Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject2, 3, 7, 8-TCDDen_US
dc.subjectcurcuminen_US
dc.subjectmyrceneen_US
dc.subjectcineoleen_US
dc.subjectoxidative stressen_US
dc.titleAntioxidative effects of curcumin, ?-myrcene and 1,8-cineole against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced oxidative stress in rats liveren_US
dc.typeArticleen_US

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