Can Melatonin Protect the Endometrium from the Adverse Effects of Caerulein?

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dc.authoridBAHAR, LEYLA/0000-0002-6910-6167
dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridGül, Semir/0000-0002-4668-9603
dc.authoridBAHAR, LEYLA/0000-0002-6910-6167
dc.authorwosidBAHAR, LEYLA/Y-3908-2019
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidGül, Semir/ABI-8244-2020
dc.authorwosidBAHAR, LEYLA/P-3890-2015
dc.contributor.authorSahin, Levent
dc.contributor.authorSahin, Hilal
dc.contributor.authorKarahan, Feride
dc.contributor.authorGul, Semir
dc.contributor.authorBahar, Leyla
dc.contributor.authorGul, Mehmet
dc.contributor.authorOzaksit, Muzeyyen Gulnur
dc.date.accessioned2024-08-04T20:40:20Z
dc.date.available2024-08-04T20:40:20Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe investigated the effects of a caerulein-induced acute pancreatitis (AP) on uterus and possible uterine protective effects of melatonin administration. Twenty-eight animals were divided into four groups: (1) control group (n = 7); (2) melatonin group (n = 7); (3) caerulein group (n = 7); (4) melatonin + caerulein group (n = 7). AP was induced by 4 intraperitoneal injection of caerulein given hourly (50 mu g/kg) into young female animals. Melatonin (20 mg/kg) was given via intraperitoneal injection 30 min prior to the induction of AP. The rats were sacrificed by decapitation 12 h after the last injection of caerulein and their uterus were taken for histopathological evaluation. Mean body weight and uterine wet weight was recorded. The H-Score method was used to score the degree of histological changes of endo-myometrium edema, hemorrhage, necrosis, leucocyte infiltration, endometrial proliferation and endometrial thickness. There was no significant difference in the mean body weight observed after treatment in each group. The uterine wet weight differences between the control and caerulein given rats were significant (P < 0.01). The endometrial thickness, edema, hemorrhage, necrosis and leucocyte infiltration of the caerulein group was significantly higher than the control and melatonin groups (P < 0.01). It was observed that preteratment with melatonin normalized histological abnormalities and significantly reduced uterine wet weight as compared with the caerulein only group. Melatonin application may play an important role in the prophylaxis of uterine endometrium arising from adverse effects of caerulein.en_US
dc.identifier.doi10.9775/kvfd.2015.13026
dc.identifier.endpage676en_US
dc.identifier.issn1300-6045
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-84934761612en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage673en_US
dc.identifier.urihttps://doi.org/10.9775/kvfd.2015.13026
dc.identifier.urihttps://hdl.handle.net/11616/96856
dc.identifier.volume21en_US
dc.identifier.wosWOS:000362666900008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKafkas Univ, Veteriner Fakultesi Dergisien_US
dc.relation.ispartofKafkas Universitesi Veteriner Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCaeruleinen_US
dc.subjectMelatoninen_US
dc.subjectUterusen_US
dc.subjectPancreatitisen_US
dc.subjectRaten_US
dc.titleCan Melatonin Protect the Endometrium from the Adverse Effects of Caerulein?en_US
dc.typeArticleen_US

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