Beneficial effects of hesperidin following cis-diamminedichloroplatinum-induced damage in heart of rats

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dc.authoriddisli, olcay murat/0000-0002-9699-4817
dc.authoridOguzturk, Hakan/0000-0002-9800-1428
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridGurbuz, Sukru/0000-0003-2616-0304
dc.authoridKaya, Kürsat/0000-0002-6353-7791
dc.authoridTurtay, Muhammet Gokhan/0000-0002-1728-8237
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authorwosiddisli, olcay murat/ABI-3289-2020
dc.authorwosidOguzturk, Hakan/AAC-3915-2021
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.authorwosidGurbuz, Sukru/ABI-3276-2020
dc.authorwosidoguzturk, hakan/Q-6242-2019
dc.authorwosidKaya, Kürsat/ABG-2848-2020
dc.authorwosidTurtay, Muhammet Gokhan/ABG-7401-2020
dc.contributor.authorOguzturk, H.
dc.contributor.authorCiftci, O.
dc.contributor.authorCetin, A.
dc.contributor.authorKaya, K.
dc.contributor.authorDisli, O. M.
dc.contributor.authorTurtay, M. G.
dc.contributor.authorGurbuz, S.
dc.date.accessioned2024-08-04T20:41:27Z
dc.date.available2024-08-04T20:41:27Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Increased oxidative stress and histopathological damage have been implicated in the cardiotoxicity that limits the clinical therapy of cisplatin (CP) as an anti-cancer drug. Objectives: This study aimed to investigate the protective effect of hesperidin (HP) against CP-induced cardiotoxicity in rats. Materials and Methods: Rats were divided into four groups (n = 7/group), and the first group served as the control group. Animals in Group CP and Group CP + HP received a single dose of CP (CP - 7 mg/kg); animals in Group HP and Group CP + HP received 50 mg/kg/day HP with gavage for 14 days. At the end of day 14, cardiac tissue samples were histologically and biochemically examined. Results: In this experimental study, thiobarbituric acid reactive substances levels in the cardiac tissue were significantly higher in the CP group, whereas glutathione (GSH), superoxide dismutase (SOD), and CAT levels were significantly lower in this group. On the other hand, GSH and SOD levels in the CP + HP group were similar to the control group. There was no significant difference in cardiac CAT levels between Group CP and Group CP + HP. Conclusion: Hesperetin treatment leads to a decrease in oxidative stress, and associated histological damage. The findings of the current study suggest that HP has a protective effect against CP-induced cardiotoxicity.en_US
dc.identifier.doi10.4103/1119-3077.173707
dc.identifier.endpage103en_US
dc.identifier.issn1119-3077
dc.identifier.issue1en_US
dc.identifier.pmid26755226en_US
dc.identifier.scopus2-s2.0-84955455022en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage99en_US
dc.identifier.urihttps://doi.org/10.4103/1119-3077.173707
dc.identifier.urihttps://hdl.handle.net/11616/97140
dc.identifier.volume19en_US
dc.identifier.wosWOS:000372830600015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofNigerian Journal of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCardiotoxicityen_US
dc.subjectcisplatinen_US
dc.subjecthesperidinen_US
dc.titleBeneficial effects of hesperidin following cis-diamminedichloroplatinum-induced damage in heart of ratsen_US
dc.typeArticleen_US

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