Cellulose acetate encapsulated upconversion nanoparticles - A novel theranostic platform

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dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridBALCIOGLU, Sevgi/0000-0003-0724-4772
dc.authoridBALCIOGLU, Sevgi/0000-0003-0724-4772
dc.authoridEricson, Marica B./0000-0002-5987-5915
dc.authoridTopel, Onder/0000-0003-1584-5519
dc.authorwosidAsilturk, Meltem/B-2989-2013
dc.authorwosidDemirel Topel, Seda/V-5165-2017
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidBALCIOGLU, Sevgi/W-5874-2018
dc.authorwosidBALCIOGLU, Sevgi/O-3576-2015
dc.authorwosidEricson, Marica B./G-4950-2016
dc.authorwosidTopel, Onder/C-2273-2016
dc.contributor.authorTopel, Seda Demirel
dc.contributor.authorBalcioglu, Sevgi
dc.contributor.authorAtes, Burhan
dc.contributor.authorAsilturk, Meltem
dc.contributor.authorTopel, Onder
dc.contributor.authorEricson, Marica B.
dc.date.accessioned2024-08-04T20:49:05Z
dc.date.available2024-08-04T20:49:05Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractLuminescent upconversion nanoparticles (UCNPs) are of great interest in a wide range of nanotechnological applications, particularly in the biomedical area like imaging and therapy but their biocompatibility and stability pose major challenges hampering progression towards further pharmaceutical applications. Herein, we present a biocompatible theranostic platform enabling simultaneous diagnosis and drug delivery consisting of UCNPs encapsulated with cellulose acetate (CA), a biocompatible polymer. Luminescence properties of UCNPs in the developed theranostic platform remain stable even after encapsulation. The size of the CA capsules, ranging from micro- to nano-sized particles, can easily be tuned by adjusting the stirring rate during encapsulation. Doxorubicin, a well-known chemotherapeutic drug, onto the CA nanocapsules containing UCNPs (UCNP-CA nanocapsules) was loaded with up to -63 % efficiency and acid-induced release (similar to 47 %) obtained at pH 3.6 and 5.5. It was found that encapsulation decreased toxicity of UCNPs as confirmed in a cellular assay (L-929 and MCF-7 cell lines). Taken together, the developed UCNP-CA nanocapsules serve as a highly interesting novel theranostic platform, combining the biocompatible optical properties of UCNP, with reduced cell toxicity and drug encapsulating properties of CA. The proposed system could be subject for further refinement and exploration.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Akdeniz University [FBA-2016-1808]; Swedish Research Council [VR 2015-05002]; Vinnova [2015-05002] Funding Source: Vinnova; Swedish Research Council [2015-05002] Funding Source: Swedish Research Councilen_US
dc.description.sponsorshipThe Scientific Research Projects Coordination Unit of Akdeniz University (project no. FBA-2016-1808) and Swedish Research Council (VR 2015-05002) are gratefully acknowledged for the financial support.en_US
dc.identifier.doi10.1016/j.mtcomm.2020.101829
dc.identifier.issn2352-4928
dc.identifier.scopus2-s2.0-85096583591en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.mtcomm.2020.101829
dc.identifier.urihttps://hdl.handle.net/11616/99644
dc.identifier.volume26en_US
dc.identifier.wosWOS:000635372800006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofMaterials Today Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCellulose acetateen_US
dc.subjectUpconversion nanoparticlesen_US
dc.subjectEncapsulationen_US
dc.subjectDoxorubicinen_US
dc.subjectpH-triggered drug releaseen_US
dc.titleCellulose acetate encapsulated upconversion nanoparticles - A novel theranostic platformen_US
dc.typeArticleen_US

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