Effects of micronised purified flavonoid fraction on pain, spermiogram and scrotal color Doppler parameters in patients with painful varicocele -: Results of a pilot study

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dc.authoridGÜNEŞ, AHMET/0000-0001-6238-2727
dc.authoridGüneş, Gülsen/0000-0003-2021-7103
dc.authorwosidDusak, Abdurrahim/A-7826-2019
dc.authorwosidGÜNEŞ, AHMET/JED-3319-2023
dc.authorwosidkılıç, süleyman/AAO-2348-2020
dc.authorwosidGüneş, Gülsen/ABG-9068-2020
dc.contributor.authorKiliç, S
dc.contributor.authorGünes, A
dc.contributor.authorIpek, D
dc.contributor.authorDusak, A
dc.contributor.authorGünes, G
dc.contributor.authorBalbay, MD
dc.contributor.authorBaydinç, YC
dc.date.accessioned2024-08-04T20:13:50Z
dc.date.available2024-08-04T20:13:50Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: Micronised purified flavonoid fraction (MPFF) is a phlebotropic drug improving venous tone, elasticity and lymphatic drainage, decreasing venous distensibility, venous emptying times, reflux time of venous blood and capillary hyperpermeability, and having antioxidant activities. Since varicocele is a venous pathology, we evaluated the effects of MPFF on pain, spermiogram and color Doppler parameters in patients with painful varicocele. Material and Methods: Semen analyses and Doppler sonography were performed in 16 patients ( aged 20 - 62 years, mean 31.2 +/- 10.9) before and after 1,000 mg/day MPFF treatment. Pain change was assessed with visual analogue scale scored between 0 and 10. Patient satisfaction with outcome and side effects were recorded. Results: Mean pain scores at 1, 3, and 6 months were 1.25 +/- 1.34, 0.25 +/- 0.68, and 0.12 +/- 0.34, respectively, all being significantly lower ( p < 0.001 for each) than baseline ( 4.93 +/- 1.77). Mean score at 12 months (0.93 +/- 1.06) was still lower than baseline ( p < 0.001) but higher than at 6 months ( p = 0.019). Respectively, 14 (87.5%) and 2 (12.5%) patients reported complete and very significant resolution of pain at the 6th month. All patients were very satisfied with the outcome. While semen volume, total sperm count, sperm concentration and morphology did not change significantly, motility increased significantly ( p = 0.009) due to decrease of grade 0 sperms ( p = 0.006) and increase of grade 3 + 4 sperms ( p < 0.001). Reflux time of left spermatic vein during the Valsalva maneuver decreased significantly ( p = 0.003). No significant change occurred in reflux time of the right spermatic vein. No side effect was recorded. Conclusions: Results of this preliminary study suggest the safety and efficacy of MPFF in the treatment of varicocele-associated pain. However, no recommendation for the use of MPFF in the treatment of pain associated with varicocele can be made before these preliminary results are confirmed by a randomized placebo-controlled trial. Copyright (C) 2005 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000083290
dc.identifier.endpage179en_US
dc.identifier.issn0042-1138
dc.identifier.issue2en_US
dc.identifier.pmid15756071en_US
dc.identifier.scopus2-s2.0-17244371185en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage173en_US
dc.identifier.urihttps://doi.org/10.1159/000083290
dc.identifier.urihttps://hdl.handle.net/11616/93883
dc.identifier.volume74en_US
dc.identifier.wosWOS:000227490200016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofUrologia Internationalisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectvaricoceleen_US
dc.subjectmicronised purified flavonoid fractionen_US
dc.subjectpainen_US
dc.subjectspermiogramen_US
dc.subjectDoppler sonographyen_US
dc.subjectconservative treatmenten_US
dc.titleEffects of micronised purified flavonoid fraction on pain, spermiogram and scrotal color Doppler parameters in patients with painful varicocele -: Results of a pilot studyen_US
dc.typeArticleen_US

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