MAT, a Novel Polyherbal Aphrodisiac Formulation, Enhances Sexual Function and Nrf2/HO-1 Pathway While Reducing Oxidative Damage in Male Rats

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dc.authoridGENCOGLU, HASAN/0000-0002-7716-552X
dc.authoridOrhan, Cemal/0000-0003-4138-7689
dc.authoridsahin, nurhan/0000-0001-9487-1154
dc.authoridSahin, Kazim/0000-0001-9542-5244
dc.authoridAkdemir, Fatih/0000-0002-5779-6631
dc.authoridTuzcu, Mehmet/0000-0002-1329-3143
dc.authoridTurk, Gaffari/0000-0001-7417-1038
dc.authorwosidGENCOGLU, HASAN/Q-2668-2015
dc.authorwosidOrhan, Cemal/Q-2086-2015
dc.authorwosidSahin, Nurhan/D-5626-2009
dc.authorwosidsahin, nurhan/ABF-8007-2020
dc.authorwosidSahin, Kazim/D-5625-2009
dc.authorwosidAkdemir, Fatih/AAG-8010-2019
dc.authorwosidTürk, Gaffari/V-6922-2018
dc.contributor.authorSahin, Kazim
dc.contributor.authorTuzcu, Mehmet
dc.contributor.authorOrhan, Cemal
dc.contributor.authorGencoglu, Hasan
dc.contributor.authorSahin, Nurhan
dc.contributor.authorAkdemir, Fatih
dc.contributor.authorTurk, Gaffari
dc.date.accessioned2024-08-04T20:44:34Z
dc.date.available2024-08-04T20:44:34Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractMucuna pruriens, Ashwagandha, and Tribulus terrestris are known as the enhancers for sexual health, functional activities, vitality, and longevity. These herbs had been widely used in the Ayurveda medicine as aphrodisiacs through the ages, and their efficacy was also verified separately in our previous publication. Therefore, the aim of this study was to determine the effects of Mucuna, Ashwagandha, and Tribulus complexes on sexual function in rats. Twenty-eight male rats allocated to four groups as follows: (i) negative control (C); (ii) positive control or sildenafil citrate treated group (5 mg/kg) (S); (iii) MAT1 (combination of 10 mg Mucuna (M) + 10 mg Ashwagandha (A) + 10 mg Tribulus (T)/kg BW); (iv) MAT 2 (20 mg Mucuna + 20 mg Ashwagandha + 20 mg Tribulus/kg BW). There was no significant difference found between the MAT1 and MAT2 groups while they showed significantly increased testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) levels when compared to the negative control. Significant increases in Nrf2/HO1 levels and decreases in NF-kappa B were detected in MAT groups similar to the decrease in serum and testis malondialdehyde (MDA) levels as compared to both controls. The spermmotility, count, and rate also significantly improved in both MAT groups, while ALT, AST, creatinine, ALP, and urea levels did not change in any of the groups. Oral consumption of MATs combination in male rats resulted in inhibition of NF-kappa B and MDA and also increased sex hormones with Nrf2-mediated HO-1 induction. MAT combinations may improve sexual functions by increasing levels of sexual hormones and regulation of NF-kappa B and Nrf2/HO-1 signaling pathways.en_US
dc.description.sponsorshipOmniActive Health Technologies (NJ, USA); Turkish Academy of Sciences (Ankara, Turkey)en_US
dc.description.sponsorshipThis study was financially supported by the OmniActive Health Technologies (NJ, USA) and partially supported by the Turkish Academy of Sciences (Ankara, Turkey). The authors are thankful to Mrs. Fusun Erten (M.S.), Mr. Besir Er (M.S.), and Mrs. Hafize Gencaban for their kind efforts during this study.en_US
dc.identifier.doi10.1155/2018/8521782
dc.identifier.issn1741-427X
dc.identifier.issn1741-4288
dc.identifier.pmid29853975en_US
dc.identifier.scopus2-s2.0-85048159148en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1155/2018/8521782
dc.identifier.urihttps://hdl.handle.net/11616/98325
dc.identifier.volume2018en_US
dc.identifier.wosWOS:000432004400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHindawi Ltden_US
dc.relation.ispartofEvidence-Based Complementary and Alternative Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTribulus-Terrestrisen_US
dc.subjectAntioxidant Activityen_US
dc.subjectStressen_US
dc.subjectSpermen_US
dc.subjectExtracten_US
dc.subjectKidneyen_US
dc.subjectPolysaccharidesen_US
dc.subjectPathogenesisen_US
dc.subjectCombinationen_US
dc.subjectDysfunctionen_US
dc.titleMAT, a Novel Polyherbal Aphrodisiac Formulation, Enhances Sexual Function and Nrf2/HO-1 Pathway While Reducing Oxidative Damage in Male Ratsen_US
dc.typeArticleen_US

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