Liver Transplantation for Hepatocellular Carcinoma: Malatya Experience and Proposals for Expanded Criteria

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dc.authoridVarol, İlknur fatma/0000-0001-5212-218X
dc.authoridTurkmen, Samdanci, Emine/0000-0002-0034-5186
dc.authoridBASKIRAN, ADIL/0000-0002-7536-1631
dc.authoridince, volkan/0000-0002-0714-490X
dc.authoridKARAKAS, SERDAR/0000-0001-8314-7806
dc.authoridAkbulut, Sami/0000-0002-6864-7711
dc.authoridSARICI, KEMAL BARIŞ/0000-0001-9595-1906
dc.authorwosidVarol, İlknur fatma/ABH-6387-2020
dc.authorwosidTurkmen, Samdanci, Emine/ABH-4716-2020
dc.authorwosidBASKIRAN, ADIL/ABI-2356-2020
dc.authorwosidince, volkan/M-7325-2017
dc.authorwosidKARAKAS, SERDAR/AAB-3219-2021
dc.authorwosidAkbulut, Sami/L-9568-2014
dc.authorwosidBarut, Bora/ABD-9882-2020
dc.contributor.authorInce, Volkan
dc.contributor.authorAkbulut, A. Sami
dc.contributor.authorOtan, Emrah
dc.contributor.authorErsan, Veysel
dc.contributor.authorKarakas, Serdar
dc.contributor.authorSahin, Tolga Tevfik
dc.contributor.authorCarr, Brian, I
dc.date.accessioned2024-08-04T20:47:23Z
dc.date.available2024-08-04T20:47:23Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractSurvival was examined from a Turkish liver transplant center of patients with HCC, to identify prognostic factors. Data from 215 patients who underwent predominantly live donor liver transplant for HCC at our institute over 12 years were included in the study and prospectively recorded. They were 152 patients within and 63 patients beyond Milan criteria. Patients beyond Milan criteria were divided into two groups according to presence or absence of tumor recurrence. Recurrence-associated factors were analyzed. These factors were then applied to the total cohort for survival analysis. We identified four factors, using multivariate analysis, that were significantly associated with tumor recurrence. These were maximum tumor diameter, degree of tumor differentiation, and serum AFP and GGT levels. A model that included all four of these factors was constructed, the 'Malatya criteria.' Using these Malatya criteria, we estimated DFS and cumulative survival, for patients within and beyond these criteria, and found statistically significant differences with improved survival in patients within Malatya criteria of 1, 5, and 10-year overall survival rates of 90.1%, 79.7%, and 72.8% respectively, which compared favorably with other extra-Milan extended criteria. Survival of our patients within the newly defined Malatya criteria compared favorably with other extra-Milan extended criteria and highlight the usefulness of serum AFP and GGT levels in decision-making.en_US
dc.identifier.doi10.1007/s12029-020-00424-w
dc.identifier.endpage1005en_US
dc.identifier.issn1941-6628
dc.identifier.issn1941-6636
dc.identifier.issue3en_US
dc.identifier.pmid32519232en_US
dc.identifier.scopus2-s2.0-85085989191en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage998en_US
dc.identifier.urihttps://doi.org/10.1007/s12029-020-00424-w
dc.identifier.urihttps://hdl.handle.net/11616/99332
dc.identifier.volume51en_US
dc.identifier.wosWOS:000539192900001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Gastrointestinal Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHepaticen_US
dc.subjectMalignancyen_US
dc.subjectLive donoren_US
dc.subjectMalatya criteriaen_US
dc.titleLiver Transplantation for Hepatocellular Carcinoma: Malatya Experience and Proposals for Expanded Criteriaen_US
dc.typeArticleen_US

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