Effects of pentoxifylline and vitamin E on the bilateral ovary after experimental ovarian ischemia

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dc.authoridbay karabulut, aysun/0000-0002-7873-2805
dc.authoridUĞURALP, SEMA/0000-0002-7628-0550
dc.authorwosidbay karabulut, aysun/HJP-0995-2023
dc.authorwosidUĞURALP, SEMA/ABH-6309-2020
dc.contributor.authorUguralp, S
dc.contributor.authorKarabulut, AB
dc.contributor.authorMizrak, B
dc.date.accessioned2024-08-04T20:14:47Z
dc.date.available2024-08-04T20:14:47Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPentoxifylline (PTX) and vitamin E inhibit the release of superoxide and hydroxyl radicals, and PTX improves capillary flow and tissue oxygenation. This experimental study was designed to determine the effects of PTX and vitamin E in the ovary after unilateral ovarian ischemia reperfusion (I-R) in albino Wistar rats. A vascular clamp was placed on the left ovary for 4 hours in all groups except for the control group. Following this, in the ischemia (1) group bilateral ovariectomy was performed. Saline, PTX, vitamin E, and PTX plus vitamin E were infused 30 min before reperfusion in the reperfusion (R), pentoxifylline (P), vitamin E (E), and pentoxifylline plus vitamin E (PE) groups, respectively. After 4 hours of reperfusion, the ovaries were removed for biochemical and histologic examination. MDA levels of bilateral ovaries in the PE group were significantly lower than in the E group (p < 0.0033). NO levels of bilateral ovaries in the PE group were significantly lower than in the P and E groups (p < 0.0033). Massive hemorrhage was determined in the ipsilateral ovaries of the R group. Hemorrhage was minimal or moderate in the ipsilateral ovaries of other groups. The contralateral ovaries showed congestion in different degrees. The contralateral ovaries of the group PE and the bilateral ovaries of the control group showed no pathological changes. PTX and vitamin E given together seems to be more effective in reducing I-R injury in ovarian tissue compared to administration of PTX, or vitamin E alone. However, further studies are required to evaluate the effective dose and duration of PTX and vitamin E on bilateral ovaries.en_US
dc.identifier.doi10.1055/s-2004-821256
dc.identifier.endpage113en_US
dc.identifier.issn0939-7248
dc.identifier.issn1439-359X
dc.identifier.issue2en_US
dc.identifier.pmid15877259en_US
dc.identifier.scopus2-s2.0-20444482850en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage107en_US
dc.identifier.urihttps://doi.org/10.1055/s-2004-821256
dc.identifier.urihttps://hdl.handle.net/11616/93970
dc.identifier.volume15en_US
dc.identifier.wosWOS:000228960400006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofEuropean Journal of Pediatric Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectovaryen_US
dc.subjectischemiaen_US
dc.subjectreperfusionen_US
dc.subjecttorsionen_US
dc.subjectpentoxifyllineen_US
dc.subjectvitamin Een_US
dc.titleEffects of pentoxifylline and vitamin E on the bilateral ovary after experimental ovarian ischemiaen_US
dc.typeArticleen_US

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