Analysis of Isotretinoin-Induced Alterations in the Levels of Plasma Trace Elements: Investigation of the Relationship Between Magnesium, Phosphorus, Potassium, Zinc, and Treatment-Related Side Effects

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dc.authoridAKMAN, Tugrul Cagri/0000-0002-5439-950X
dc.contributor.authorAkman, Tugrul Cagri
dc.contributor.authorYazici, Mustafa
dc.contributor.authorAtila, Alptug
dc.contributor.authorMertoglu, Cuma
dc.date.accessioned2024-08-04T20:54:59Z
dc.date.available2024-08-04T20:54:59Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIsotretinoin is an effective treatment against acne vulgaris, but it also causes many side effects during and after the treatment. The relationship between the changes in the levels of plasma trace elements of patients with AV after 3 months of isotretinoin treatment and the side effects was investigated in the study. Plasma samples of 35 patients were collected before and after isotretinoin treatment. Samples were analyzed by Inductively Coupled Plasma-Mass Spectrometer. After treatment, the levels of phosphorus, magnesium, and zinc in plasma increased statistically, while the level of potassium decreased (p < 0.05). The treatment had differing effects on zinc levels based on the gender of the individuals. With treatment, the levels of zinc in the plasma of men showed a greater increase compared to women (p = 7.3e-04). Additionally, the correlation matrix analysis revealed a strong correlation (R > 0.8) between magnesium and calcium. According to the study results, the change in phosphorus and potassium levels shows that isotretinoin affects kidney functions. The results suggest that phosphorus, potassium, magnesium, and zinc are associated with fatigue, dry skin and chapped lips, hair loss, and sebum secretion, respectively. Consequently, the study emphasizes the need for a comprehensive pre-treatment assessment, including monitoring of liver and kidney function as well as the levels of phosphorus and potassium in patients.en_US
dc.description.sponsorshipResearch Fund of Erzincan Binali Yimath;ldimath;rimath;m Universityen_US
dc.description.sponsorshipNo Statement Availableen_US
dc.identifier.doi10.1007/s12011-023-04053-9
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.pmid38197903en_US
dc.identifier.scopus2-s2.0-85182247960en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-023-04053-9
dc.identifier.urihttps://hdl.handle.net/11616/101768
dc.identifier.wosWOS:001139543800003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcneen_US
dc.subjectSeverityen_US
dc.titleAnalysis of Isotretinoin-Induced Alterations in the Levels of Plasma Trace Elements: Investigation of the Relationship Between Magnesium, Phosphorus, Potassium, Zinc, and Treatment-Related Side Effectsen_US
dc.typeArticleen_US

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