Evaluation of Renal Functions in Preterm Infants With Respiratory Distress Syndrome

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dc.authoridÖncül, Mehmet/0000-0001-5874-7826
dc.authoridElmas, Ahmet Taner/0000-0002-9749-6115
dc.authorwosidTabel, Yilmaz/AAF-9801-2020
dc.authorwosidÖncül, Mehmet/ABV-4995-2022
dc.authorwosidELMAS, Ahmet Taner/W-4101-2017
dc.authorwosidElmas, Ahmet Taner/ABI-1338-2020
dc.contributor.authorTabel, Yilmaz
dc.contributor.authorOncul, Mehmet
dc.contributor.authorElmas, Ahmet Taner
dc.contributor.authorGungor, Serdal
dc.date.accessioned2024-08-04T20:39:48Z
dc.date.available2024-08-04T20:39:48Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: The aim of this prospective study was to evaluate urinary glutathione S transferases p (GST-pi), beta-2-microglobulin (B2-MG), and N-acetyl-beta-D-glucosaminidase (NAG) levels as markers revealing the effect of respiratory distress syndrome (RDS) on renal function in preterm infants. Methods: The study was performed with 76 preterm infants whose gestational ages were between 28 and 32 weeks. Twenty-six preterm infants with RDS (cases) and 50 preterm infants without RDS (controls) enrolled in the study. Blood and urine samples were obtained on postnatal (PN) day 3 and 30. Urinary GSTp levels were measured by enzyme-linked immunosorbent assay (ELISA), and urinary B2-MG levels were determined by nephelometric method. Results: There was no significant difference in urinary B2-MG and GST-pi levels between RDS and non-RDS groups on PN day 3 (P > 0.05 for each). However, preterm infants with RDS had significantly higher urinary B2-MG and GSTp levels than the control group on PN day 30 (P = 0.0001 and P = 0.031, respectively). Urinary NAG levels were higher in RDS group than those of the controls on both PN day 3 and 30, but these findings were not statistically significant (P > 0.05, for each). Conclusion: Preterm infants with RDS had increased levels of both GST-p and B2-MG levels on PN day 30, suggesting subclinical tubular dysfunction, probably secondary to hypoxic stress. (C) 2014 Wiley Periodicals, Inc.en_US
dc.identifier.doi10.1002/jcla.21686
dc.identifier.endpage314en_US
dc.identifier.issn0887-8013
dc.identifier.issn1098-2825
dc.identifier.issue4en_US
dc.identifier.pmid24578235en_US
dc.identifier.scopus2-s2.0-84904120821en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage310en_US
dc.identifier.urihttps://doi.org/10.1002/jcla.21686
dc.identifier.urihttps://hdl.handle.net/11616/96503
dc.identifier.volume28en_US
dc.identifier.wosWOS:000339551900010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJohn Wiley & Sons Incen_US
dc.relation.ispartofJournal of Clinical Laboratory Analysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectbeta-2-microglobulinen_US
dc.subjectglutathione S-transferase pien_US
dc.subjectN-acetyl-beta-D-glucosaminidaseen_US
dc.subjectpreterm infantsen_US
dc.subjectrenal functionen_US
dc.subjectrespiratory distress syndromeen_US
dc.titleEvaluation of Renal Functions in Preterm Infants With Respiratory Distress Syndromeen_US
dc.typeArticleen_US

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