The Prolidase Activity, Oxidative Stress, and Nitric Oxide Levels of Bladder Tissues with or Without Tumor in Patients with Bladder Cancer

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dc.authoridMeral, Ismail/0000-0002-0973-4305
dc.authoridGeçit, İlhan/0000-0001-7329-6971
dc.authoridPirincci, Necip/0000-0002-5494-0984
dc.authoridGUNES, MUSTAFA/0000-0003-2044-9086
dc.authorwosidgunes, mustafa/AAR-9915-2020
dc.authorwosidMeral, Ismail/O-7139-2019
dc.authorwosidkavak, servet/ABB-6429-2020
dc.authorwosidGeçit, İlhan/ABI-8258-2020
dc.authorwosidPirincci, Necip/W-7637-2018
dc.contributor.authorGecit, Ilhan
dc.contributor.authorEryilmaz, Recep
dc.contributor.authorKavak, Servet
dc.contributor.authorMeral, Ismail
dc.contributor.authorDemir, Halit
dc.contributor.authorPirincci, Necip
dc.contributor.authorGunes, Mustafa
dc.date.accessioned2024-08-04T20:43:57Z
dc.date.available2024-08-04T20:43:57Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study was designed to evaluate the malondialdehyde (MDA), glutathione (GSH) and nitric oxide (NO) levels, and also prolidase, glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) enzyme activities in malignant and benign cancers of bladder tissue. A total of 59 patients admitted to our clinic due to microscopic or macroscopic haematuria, were prospectively included in the study. Because of some reasons (no request to participate in the study, the inability to reach, other malignancies, alcohol consumption, metabolic disease), eight patients were excluded from study. Of the 51 patients, 25 were bladder tumor patients, and 26 were patients without cancers. The bladder tissue samples were obtained from all patients under anesthesia (spinal, epidural or general) for the measurement of MDA, GSH and NO levels, and prolidase, GSH-Px and SOD enzyme activities. Among the patients with bladder cancers, 7 patients were females and 18 patients were males, with an average age of 68.4 +/- 2.49. Among patients without tumors, 6 patients were females and 20 patients were males, with an average age of 58 +/- 2.05. In patients with bladder tumors, the oxidants (MDA, NO, prolidase) were higher, and the antioxidants (SOD, GSH, GSH-Px) were lower than those in patients without tumors. It was concluded that the oxygen free radicals play a role in the etiology of bladder cancers similar to many other tumors and inflammatory conditions. Therefore, we assume that antioxidants may provide benefits in the prevention and treatment of bladder cancer.en_US
dc.identifier.doi10.1007/s00232-017-9971-0
dc.identifier.endpage459en_US
dc.identifier.issn0022-2631
dc.identifier.issn1432-1424
dc.identifier.issue5en_US
dc.identifier.pmid28815271en_US
dc.identifier.scopus2-s2.0-85027501034en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage455en_US
dc.identifier.urihttps://doi.org/10.1007/s00232-017-9971-0
dc.identifier.urihttps://hdl.handle.net/11616/97932
dc.identifier.volume250en_US
dc.identifier.wosWOS:000411904600005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Membrane Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCanceren_US
dc.subjectBladderen_US
dc.subjectStatus antioxidantsen_US
dc.subjectSuperoxide dismutaseen_US
dc.subjectNitric oxideen_US
dc.subjectOxidative stressen_US
dc.titleThe Prolidase Activity, Oxidative Stress, and Nitric Oxide Levels of Bladder Tissues with or Without Tumor in Patients with Bladder Canceren_US
dc.typeArticleen_US

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