Ru(ii)-N-heterocyclic carbene complexes: synthesis, characterization, transfer hydrogenation reactions and biological determination

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dc.authoridÖzdemir, İsmail/0000-0001-6325-0216
dc.authoridYaşar, Sedat/0000-0001-7285-2761
dc.authoridMansour, Lamjed/0000-0002-9415-9383
dc.authoridHarrath, Abdel Halim/0000-0002-2170-1303
dc.authorwosidÖzdemir, İsmail/ABI-5192-2020
dc.authorwosidMANSOUR, Lamjed/AAO-6201-2020
dc.authorwosidabutaha, nael/AAX-4443-2021
dc.authorwosidYaşar, Sedat/ABG-8356-2020
dc.authorwosidMansour, Lamjed/U-3028-2017
dc.authorwosidchakchouk, ahlem/JYP-3425-2024
dc.authorwosidHarrath, Abdel Halim/K-2166-2014
dc.contributor.authorBoubakri, Lamia
dc.contributor.authorChakchouk-Mtibaa, A.
dc.contributor.authorAl-Ayed, Abdullah S.
dc.contributor.authorMansour, L.
dc.contributor.authorAbutaha, Nael
dc.contributor.authorHarrath, Abdel Halim
dc.contributor.authorMellouli, L.
dc.date.accessioned2024-08-04T20:46:54Z
dc.date.available2024-08-04T20:46:54Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractA series of ruthenium(ii) complexes with N-heterocyclic carbene ligands were successfully synthesized by transmetalation reactions between silver(i) N-heterocyclic carbene complexes and [RuCl2(p-cymene)](2) in dichloromethane under Ar conditions. All new compounds were characterized by spectroscopic and analytical methods. These ruthenium(ii)-NHC complexes were found to be efficient precatalysts for the transfer hydrogenation of ketones by using 2-propanol as the hydrogen source in the presence of KOH as a co-catalyst. The antibacterial activity of ruthenium N-heterocyclic carbene complexes 3a-f was measured by disc diffusion method against Gram positive and Gram-negative bacteria. Compounds 3d exhibited potential antibacterial activity against five bacterial species among the six used as indicator cells. The product 3e inhibits the growth of all the six tested microorganisms. Moreover, the antioxidant activity determination of these complexes 3a-f, using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2 '-azinobis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS) as reagent, showed that compounds 3b and 3d possess DPPH and ABTS antiradical activities. From a concentration of 1 mg ml(-1), these two complexes presented a similar scavenging activity to that of the two used controls gallic acid (GA) and butylated hydroxytoluene (BHT). From a concentration of 10 mg ml(-1), the percentage inhibition of complexes 3b and 3d was respectively 70% and 90%. In addition, these two Ru-NHC complexes exhibited antifungal activity against Candida albicans. Investigation of the anti-acetylcholinesterase activity of the studied complexes showed that compounds 3a, 3b, 3d and 3e exhibited good activity at 100 mu g ml(-1) and product 3d is the most active. In a cytotoxicity study the complexes 3 were evaluated against two human cancer cell lines MDA-MB-231 and MCF-7. Both 3d and 3e complexes were found to be active against the tested cell lines showing comparable activity with examples in the literature.en_US
dc.description.sponsorshipResearch Supporting Project, King Saud University, Riyadh Saudi Arabia [RSP-2019/75]en_US
dc.description.sponsorshipThis work was financed by the Research Supporting Project (RSP-2019/75), Kig Saud Univernsity, Riyadh Saudi Arabia.en_US
dc.identifier.doi10.1039/c9ra05605j
dc.identifier.endpage34420en_US
dc.identifier.issn2046-2069
dc.identifier.issue59en_US
dc.identifier.pmid35529977en_US
dc.identifier.scopus2-s2.0-85074594147en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage34406en_US
dc.identifier.urihttps://doi.org/10.1039/c9ra05605j
dc.identifier.urihttps://hdl.handle.net/11616/99018
dc.identifier.volume9en_US
dc.identifier.wosWOS:000494684600036en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherRoyal Soc Chemistryen_US
dc.relation.ispartofRsc Advancesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectN-Heterocyclic Carbenesen_US
dc.subjectOlefin Metathesisen_US
dc.subjectMetal-Complexesen_US
dc.subjectCatalystsen_US
dc.subjectReactivityen_US
dc.subjectLiganden_US
dc.subjectAlkaloidsen_US
dc.subjectAldehydesen_US
dc.subjectAlcoholsen_US
dc.subjectIminesen_US
dc.titleRu(ii)-N-heterocyclic carbene complexes: synthesis, characterization, transfer hydrogenation reactions and biological determinationen_US
dc.typeArticleen_US

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