Ankaferd Blood Stopper Is More Effective Than Adrenaline Plus Lidocaine and Gelatin Foam in the Treatment of Epistaxis in Rabbits

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dc.authoridHaznedaroglu, Ibrahim C./0000-0001-8028-9462
dc.authoridTurkmen, Samdanci, Emine/0000-0002-0034-5186
dc.authoridMiman, Murat Cem/0000-0002-2139-9239;
dc.authorwosidKALCIOGLU, Mahmut Tayyar/I-5884-2013
dc.authorwosidHaznedaroglu, Ibrahim C./AAB-2114-2019
dc.authorwosidTurkmen, Samdanci, Emine/ABH-4716-2020
dc.authorwosidMiman, Murat Cem/AAZ-4873-2020
dc.authorwosidKalcioglu, M. Tayyar/JAC-1515-2023
dc.contributor.authorKelles, Mehmet
dc.contributor.authorKalcioglu, M. Tayyar
dc.contributor.authorSamdanci, Emine
dc.contributor.authorSelimoglu, Erol
dc.contributor.authorIraz, Mustafa
dc.contributor.authorMiman, Murat Cem
dc.contributor.authorHaznedaroglu, Ibrahim C.
dc.date.accessioned2024-08-04T20:35:35Z
dc.date.available2024-08-04T20:35:35Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBACKGROUND: Epistaxis is an important emergency that can sometimes be life threatening without effective intervention. Persistent and recurrent bleeding can lead to aspiration, hypotension, hypoxia, or even severe and mortal cardiovascular complications. Providing prompt hemostasis is important, and the hemostatic method used must be easily and locally applicable, efficient, and inexpensive. OBJECTIVE: The aim of this study was to assess the hemostatic efficacy of Ankaferd Blood Stopper (ABS) in an experimental epistaxis model and to determine the histopathologic alterations with topical ABS application. METHODS: Twenty-eight New Zealand rabbits were evaluated in 4 study groups. Topical ABS, gelatin foam (GF), adrenalin + lidocaine (AL), and serum physiologic as negative control (C) were applied to the animals for controlling epistaxis. The bleeding was generated with a standard mucosal incision in all groups. Cotton pieces soaked with ABS, AL, C, and GF were applied to the nasal bleeding area. Time of hemostasis was recorded. Tissue samples were obtained after hemostasis for histopathologic examination. The samples were stained with hematoxylin and eosin (HE) and phosphotungstic acid hematoxylin (PTAH) and were examined under a light microscope. In this experimental study, the observers were blind to ABS, AL, and C but not to GF, because of its solid nature. RESULTS: Median durations required for hemostasis in ABS, AL, GF, and C groups were recorded as 30, 90, 90, and 210 seconds, respectively. The time until termination of bleeding in the ABS group was significantly shorter than that in the AL, GF, and C groups (P = 0.002, P = 0.002, and P = 0.001, respectively). On histopathologic evaluation, after staining with HE, minimal fibrin at the incision edges and a few extravasated erythrocytes were observed in the C, AL, and GF groups. In the ABS group, a dark amorphous material surrounded by fibrin, filling the space between the edges of incisions, was noticed. Fibrin was determined in the C, GF, and AL groups with PTAH stain and in the positive control group. In the ABS group, it was observed that the amorphous substance surrounded by fibrin seen in the HE sections was not stained with PTAH. CONCLUSIONS: Topical nasal ABS application controlled epistaxis faster than C, GF, and AL in this animal bleeding model. The bleeding model used here might fail to replicate the type of injury that would be likely to result in life-threatening bleeding in humans, which should be considered a limitation of the present study. The histopathologic findings in the nasal incision area suggest that ABS might affect global hemostasis by inducing a unique protein network formation, potentially representing a different mechanism of action among conventional antihemorrhagic applications. (Curr Ther Res Clin Exp. 2011;72:185-194) (C) 2011 Elsevier HS Journals, Inc. All rights reserved.en_US
dc.description.sponsorshipInonu University, Malatya, Turkeyen_US
dc.description.sponsorshipThis was research supported by the Research Fund of the Inonu University, Malatya, Turkey. The authors would also like to thank Saim Yologlu, MD, Inonu University Medical Faculty Department of Biostatistics, for statistical evaluation. The authors do not have any relationship with the commercial company of the product tested (ABS). The authors have indicated that they have no other conflicts of interest regarding the content of this article.en_US
dc.identifier.doi10.1016/j.curtheres.2011.08.002
dc.identifier.endpage194en_US
dc.identifier.issn0011-393X
dc.identifier.issn1879-0313
dc.identifier.issue5en_US
dc.identifier.pmid24648588en_US
dc.identifier.scopus2-s2.0-80054014670en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage185en_US
dc.identifier.urihttps://doi.org/10.1016/j.curtheres.2011.08.002
dc.identifier.urihttps://hdl.handle.net/11616/95456
dc.identifier.volume72en_US
dc.identifier.wosWOS:000296211700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofCurrent Therapeutic Research-Clinical and Experimentalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnkaferd Blood Stopperen_US
dc.subjectepinephrineen_US
dc.subjectepistaxisen_US
dc.subjectgelatin foamen_US
dc.subjectlidocaineen_US
dc.subjectrabbiten_US
dc.titleAnkaferd Blood Stopper Is More Effective Than Adrenaline Plus Lidocaine and Gelatin Foam in the Treatment of Epistaxis in Rabbitsen_US
dc.typeArticleen_US

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