Poly(2-hydroxyethyl methacrylate)/boric acid composite hydrogel as soft contact lens material: Thermal, optical, rheological, and enhanced antibacterial properties

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dc.authoridUlu, Ahmet/0000-0002-4447-6233
dc.authoridBALCIOGLU, Sevgi/0000-0003-0724-4772
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridBALCIOGLU, Sevgi/0000-0003-0724-4772
dc.authoridKoytepe, Suleyman/0000-0002-4788-278X
dc.authorwosidUlu, Ahmet/L-5180-2016
dc.authorwosidBALCIOGLU, Sevgi/W-5874-2018
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidBirhanli, Emre/AAA-4009-2021
dc.authorwosidKöytepe, Süleyman/AAA-4168-2021
dc.authorwosidBALCIOGLU, Sevgi/O-3576-2015
dc.contributor.authorUlu, Ahmet
dc.contributor.authorBalcioglu, Sevgi
dc.contributor.authorBirhanli, Emre
dc.contributor.authorSarimeseli, Ayse
dc.contributor.authorKeskin, Rukiye
dc.contributor.authorKoytepe, Suleyman
dc.contributor.authorAtes, Burhan
dc.date.accessioned2024-08-04T20:44:27Z
dc.date.available2024-08-04T20:44:27Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe present work proposes to fabricate a composite hydrogel material that well characterized, transparent, biocompatible, and self-antibacterial as potential soft contact lens material. For this purpose, poly(2-hydroxyethyl methacrylate) (PHEMA)/boric acid (BA) composite hydrogels were successfully prepared by chemical crosslinking with BA through in situ polymerization using different BA ratios between 1 and 10% w/w. Afterward, the compositions, thermal stability, transparence, oxygen permeability, water uptake capacity, swelling ratio as well as morphological and rheological properties, in vitro degradability, in vitro cytotoxicity, and antibacterial properties of the all prepared materials were analyzed using a series of different techniques. The thermal stability, hydrophilicity, water uptake, oxygen permeability gradually increased depending ratio of BA, which is desirable for biomaterial. While the transparence and refractive index decreased, the composite hydrogels, except for BA content of 10 wt %, maintained enough transparency to be used for contact lens. In addition, PHEMA/BA composite hydrogels exhibited good cytocompatibility (PHEMA-1%BA and PHEMA-3%BA) and excellent antibacterial activity against Gram-positive (Staphylococcus aureus and Enterococcus faecium) and Gram-negative (Escherichia coli and Pseudomonas aeruginosa) bacteria. Overall, the results demonstrated that the obtained PHEMA/BA composite hydrogels could be considered as self-antibacterial contact lens and a potential composite biomaterial for other applications. (c) 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46575.en_US
dc.description.sponsorshipInonu University Scientific Research Projects Unit; TUBITAK-BIDEB (Scientific and Technical Research Council of Turkey-Department of Science Fellowships and Grant Programmes (BIDEB)) [2209-A]en_US
dc.description.sponsorshipThis work was supported by the TUBITAK-BIDEB (Scientific and Technical Research Council of Turkey-Department of Science Fellowships and Grant Programmes (BIDEB) under grant no.2209-A and partially supported by The Inonu University Scientific Research Projects Unit.en_US
dc.identifier.doi10.1002/app.46575
dc.identifier.issn0021-8995
dc.identifier.issn1097-4628
dc.identifier.issue35en_US
dc.identifier.scopus2-s2.0-85046146570en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/app.46575
dc.identifier.urihttps://hdl.handle.net/11616/98260
dc.identifier.volume135en_US
dc.identifier.wosWOS:000435940900001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Applied Polymer Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbiocompatibilityen_US
dc.subjectbiodegradableen_US
dc.subjectbiomaterialsen_US
dc.subjectbiomedical applicationsen_US
dc.subjectcompositesen_US
dc.titlePoly(2-hydroxyethyl methacrylate)/boric acid composite hydrogel as soft contact lens material: Thermal, optical, rheological, and enhanced antibacterial propertiesen_US
dc.typeArticleen_US

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