Fish oil, contained in eicosapentaenoic acid and docosahexaenoic acid, attenuates testicular and spermatological damage induced by cisplatin in rats

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dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridKaya, Kürsat/0000-0002-6353-7791
dc.authoridaydin, muhterem/0000-0002-6494-9229
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.authorwosidKaya, Kürsat/ABG-2848-2020
dc.authorwosidaydin, muhterem/W-4192-2018
dc.contributor.authorCiftci, O.
dc.contributor.authorCetin, A.
dc.contributor.authorAydin, M.
dc.contributor.authorKaya, K.
dc.contributor.authorOguz, F.
dc.date.accessioned2024-08-04T20:40:00Z
dc.date.available2024-08-04T20:40:00Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the beneficial effects of the fish oil (FO) supplementation on oxidative stress, sperm characteristics and histological alterations in the male reproductive system of rats against cisplatin (CP) toxicity. The rats were divided randomly into 4 equal groups (control, FO, CP and FO+CP). FO was orally administered at the dose of 1softgel per rat per day for 14days and CP was intraperitoneally given at the dose of 7mgkg(-1) with a single injection. In CP+FO group, they were applicated at the same doses and times. The results showed that CP caused a significant oxidative damage via induction of lipid peroxidation and reduction in the antioxidant defence system potency in the testis tissue. In addition, sperm motility and sperm concentration significantly decreased but the abnormal sperm rate and histopathological testicular damage increased with CP treatment. On the other hand, FO treatment prevented oxidative, histopathological and spermatological effects of CP and reversed side effects of CP. In conclusion, FO supplementation had significant beneficial effects against CP toxicity on male reproductive system and toxic effects of CP can be prevented by FO treatment. Therefore, it appears that fish oil may be useful for the prevention and treatment of cisplatin-induced reproductive system toxicity.en_US
dc.identifier.doi10.1111/and.12209
dc.identifier.endpage1168en_US
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue10en_US
dc.identifier.pmid24350676en_US
dc.identifier.scopus2-s2.0-84920274044en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1161en_US
dc.identifier.urihttps://doi.org/10.1111/and.12209
dc.identifier.urihttps://hdl.handle.net/11616/96647
dc.identifier.volume46en_US
dc.identifier.wosWOS:000344913900012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAbnormal sperm rateen_US
dc.subjectcisplatinen_US
dc.subjectfish oilen_US
dc.subjectsperm concentrationen_US
dc.subjecttesticular damageen_US
dc.titleFish oil, contained in eicosapentaenoic acid and docosahexaenoic acid, attenuates testicular and spermatological damage induced by cisplatin in ratsen_US
dc.typeArticleen_US

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