Effects of misoprostol on bone loss in ovariectomized rats

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dc.authoridKutlu, Ramazan/0000-0001-7941-7025
dc.authorwosidKutlu, Ramazan/B-1624-2016
dc.contributor.authorSonmez, AS
dc.contributor.authorBirincioglu, M
dc.contributor.authorÖzer, MK
dc.contributor.authorKutlu, R
dc.contributor.authorChuong, CJ
dc.date.accessioned2024-08-04T20:12:00Z
dc.date.available2024-08-04T20:12:00Z
dc.date.issued1999
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study was performed to investigate whether misoprostol (prostaglandin Fl analogue) (Cytotec, Searle, England) is effective for restoration of bone loss. Four-month-old parous female Sprague-Dawley rats (n = 30) were subjected either to bilateral ovariectomy (OVX, 24 fats) or to sham surgery (sham, 6 rats), The OVX rats were divided into four groups 60 days after the surgery. Six of them were killed, and dual-energy X-ray absorption (Norland xr-36, Norland Corporation, Fort Atkinson, WI, USA) measurements were performed, called pretreatment OVX group. The remaining groups teach had 6 rats) treated orally with 0 (control), 100, 200 mu g/kg/day misoprostol for 60 days. All rats were killed 60 days after having treatment, and bone loss of the lumbar spine was measured by dual-energy X-ray absorption. The bone mineral density was decreased by 25.4% in control group and 23.6% in pretreatment group compared to sham group, but restored by 86% and 96% in groups treated with 100 and 200 mu g/kg/day misoprostol, respectively. These results suggest that misoprostol restores bone loss in the lumbar spine of OVX rats in a dose-dependent manner. (C) 1999 Elsevier Science Inc. All rights reserved.en_US
dc.identifier.doi10.1016/S0090-6980(98)00080-X
dc.identifier.endpage118en_US
dc.identifier.issn0090-6980
dc.identifier.issue2-3en_US
dc.identifier.pmid10410382en_US
dc.identifier.scopus2-s2.0-0032766048en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage113en_US
dc.identifier.urihttps://doi.org/10.1016/S0090-6980(98)00080-X
dc.identifier.urihttps://hdl.handle.net/11616/93154
dc.identifier.volume57en_US
dc.identifier.wosWOS:000081544800005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofProstaglandins & Other Lipid Mediatorsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmisoprostolen_US
dc.subjectbone mineral densityen_US
dc.subjectovariectomized raten_US
dc.titleEffects of misoprostol on bone loss in ovariectomized ratsen_US
dc.typeArticleen_US

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