Implications of FAD Electrode Reaction Kinetics for Electrocatalysis of NADH Oxidation and Development of NAD-Dependent Enzyme Electrodes

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dc.authoridEMRE, Fatma Bilge/0000-0002-2972-5596
dc.authoridEmre, Fatma Bilge/0000-0002-2972-5596
dc.authoridLOPES, Paula/0000-0003-4034-7722
dc.authoridFerapontova, Elena E./0000-0003-1177-3204
dc.authorwosidEMRE, Fatma Bilge/AAS-3969-2020
dc.authorwosidEmre, Fatma Bilge/V-5662-2017
dc.authorwosidLOPES, Paula/AAV-3065-2021
dc.contributor.authorEmre, Fatma Bilge
dc.contributor.authorLopes, Paula
dc.contributor.authorFerapontova, Elena E.
dc.date.accessioned2024-08-04T20:39:43Z
dc.date.available2024-08-04T20:39:43Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractFAD entrapped into the polyethyleneimine (PEI) matrix underwent 2e(-)/2H(+) redox transformation, in contrast to the 1e(-)/1H(+) reaction observed with non-stabilized FAD-modified electrodes. Under conditions of the 2e(-)/2H(+) reaction, FAD/PEI-modified electrodes catalytically oxidized NADH starting from -100 mV vs. Ag/AgCl. These electrodes may be used for construction of NAD-dependent dehydrogenase electrodes for clinically important analytes such as glucose when coupled to the model enzyme glucose dehydrogenase. Latter allows detection of glucose starting from -100 mV within 0.05-5 mM concentration range. These results suggest the FAD stabilization by different matrices as a simple and promising approach to achieve its 2e(-)/2H(+) redox chemistry resulting in catalysis of NADH oxidation.en_US
dc.description.sponsorshipAarhus University; Danish Council for Independent Research, Natural Sciences (FNU) [11-107176]en_US
dc.description.sponsorshipThe work was supported by the Aarhus University Starting Grant to EF and the Danish Council for Independent Research, Natural Sciences (FNU), Project Number 11-107176.en_US
dc.identifier.doi10.1002/elan.201400048
dc.identifier.endpage1361en_US
dc.identifier.issn1040-0397
dc.identifier.issn1521-4109
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-84902001088en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1354en_US
dc.identifier.urihttps://doi.org/10.1002/elan.201400048
dc.identifier.urihttps://hdl.handle.net/11616/96472
dc.identifier.volume26en_US
dc.identifier.wosWOS:000337690700022en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofElectroanalysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFlavin adenine dinucleotide (FAD)en_US
dc.subjectNADH oxidationen_US
dc.subjectPolyethyleneimine (PEI)en_US
dc.subjectNAD-dependent glucose dehydrogenaseen_US
dc.subjectElectrocatalysisen_US
dc.titleImplications of FAD Electrode Reaction Kinetics for Electrocatalysis of NADH Oxidation and Development of NAD-Dependent Enzyme Electrodesen_US
dc.typeArticleen_US

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