The Prevalence of Previous Coronavirus Disease-19 in Patients with Pulmonary Thromboembolism and Its Effect on Embolism Severity

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dc.contributor.authorKocak, Nagihan Durmus
dc.contributor.authorTutar, Nuri
dc.contributor.authorCil, Gizem
dc.contributor.authorAfsin, Emine
dc.contributor.authorSenturk, Aysegul
dc.contributor.authorAydin, Derya
dc.contributor.authorMermit, Buket
dc.date.accessioned2026-04-04T13:31:04Z
dc.date.available2026-04-04T13:31:04Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractBackground/Objectives: The association between past coronavirus disease-19 (COVID-19) infection and pulmonary thromboembolism (PTE) is a potential research topic. We aimed to research the prevalence of previous COVID-19 infection in patients with PTE and to determine whether there is a difference in embolism severity in these cases. Methods: Study design: Multicenter, observational, cross-sectional. Patients diagnosed with PTE between 11 March 2022 and 11 March 2023 were prospectively included in this study, excluding cases with PTE along with active COVID-19, patients under the age of 18, and pregnant patients. Group 1 consisted of PTE cases with previous COVID-19, and Group 2 consisted of PTE cases without previous COVID-19. Key variables are D-Dimer level, right ventricle/left ventricle (RV/LV) ratio, simplified pulmonary embolism severity score, and treatment type. Results: A total of 1185 patients (Group 1; n = 360, Group 2; n = 825) were included in this study. The proportion of patients with RV/LV ratio > 1 on computed tomography pulmonary angiography (CTPA) was significantly high in Group 2 compared to Group 1 (27.9% vs. 19.7%, p = 0.003). In multivariate logistic regression analysis, the absence of any identifiable risk factor for PTE was found to be a 0.46-fold protective factor in the presence of previous COVID-19 (OR: 0.456 95% CI: 0.274-0.760, Wald = 9.070, df = 1, p = 0.003) and an RV/LV ratio > 1 on CTPA was found to be a 0.60-fold protective factor (OR: 0.603, 95% CI: 0.365-0.998, Wald = 3.874, df = 1, p = 0.049). Conclusions: The prevalence of previous COVID-19 infection in PTE cases was 30.4%, and 26.3% of idiopathic cases had previous COVID-19 infection. Although the parameters related to embolism severity were higher in the non-COVID-19 group, multivariate analyses revealed a 2.2-fold increased risk for idiopathic PTE and a 1.7-fold increased risk for RV/LV ratio > 1 on CTPA in patients without COVID-19 compared to those with prior COVID-19.
dc.identifier.doi10.3390/jcm14061909
dc.identifier.issn2077-0383
dc.identifier.issue6
dc.identifier.orcid0000-0002-3670-8508
dc.identifier.orcid0000-0001-9318-0458
dc.identifier.orcid0000-0002-6456-6623
dc.identifier.orcid0000-0002-0973-9173
dc.identifier.orcid0000-0002-1994-6723
dc.identifier.orcid0000-0003-1579-3392
dc.identifier.orcid0000-0001-8724-5331
dc.identifier.pmid40142721
dc.identifier.scopus2-s2.0-105001230140
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/jcm14061909
dc.identifier.urihttps://hdl.handle.net/11616/108563
dc.identifier.volume14
dc.identifier.wosWOS:001454064500001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofJournal of Clinical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectCOVID-19
dc.subjecthospital mortality
dc.subjectpatient acuity
dc.subjectpulmonary embolism
dc.subjectrisk factors
dc.titleThe Prevalence of Previous Coronavirus Disease-19 in Patients with Pulmonary Thromboembolism and Its Effect on Embolism Severity
dc.typeArticle

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