Effects of 2 Different Doses of Pregabalin on Morphine Consumption and Pain After Abdominal Hysterectomy: A Randomized, Double-Blind Clinical Trial

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dc.authoridaydogan, mustafa said/0000-0002-7106-1156
dc.authoridDurmus, Mahmut/0000-0001-9594-9064
dc.authoridGan, Lin/0000-0002-2263-8836
dc.authoridYücel, Aytaç/0000-0003-0270-8339
dc.authoridÇOLAK, CEMİL/0000-0001-5406-098X
dc.authoridErsoy, Mehmet/0000-0002-0724-2825
dc.authorwosidaydogan, mustafa said/AAA-2828-2021
dc.authorwosidDurmus, Mahmut/ABH-3006-2020
dc.authorwosidGan, Lin/JCE-8154-2023
dc.authorwosidDurmuş, Mahmut/AAG-3377-2019
dc.authorwosidYücel, Aytaç/ABI-6137-2020
dc.authorwosidÇOLAK, CEMİL/ABI-3261-2020
dc.authorwosidErsoy, Mehmet/ACN-2779-2022
dc.contributor.authorYucel, Aytac
dc.contributor.authorOzturk, Erdogan
dc.contributor.authorAydogan, M. Said
dc.contributor.authorDurmus, Mahmut
dc.contributor.authorColak, Cemil
dc.contributor.authorErsoy, M. Ozcan
dc.date.accessioned2024-08-04T20:35:32Z
dc.date.available2024-08-04T20:35:32Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBACKGROUND: Pregabalin has a similar pharmacologic profile to that of its developmental predecessor gabapentin but has shown greater analgesic activity in rodent models of neuropathic pain. OBJECTIVE: The objective of the study was to compare the effects of 2 different doses of pregabalin and placebo on postoperative pain and morphine consumption. METHODS: Ninety patients who underwent abdominal hysterectomy were included in the study and randomly divided into 3 groups in a doubled-blinded manner. They were given 150 mg of pregabalin (group P300, n = 30), 300 mg of pregabalin (group P600, n = 30), or placebo capsules (group C, n = 30) 4 hours before the induction of anesthesia; they received a second dose of the drug 12 hours postoperatively. Morphine consumption, nausea, and vomiting, visual analogue scale-pain intensity (VAS-PI), sedation scores, and dissatisfaction scores were recorded in the postanesthesia care unit (PACU) and at 2, 4, 6, and 24 hours after operation. RESULTS: Morphine consumption at 24 hours was 40.80 (3.42) mg, 33.79 (5.77) mg, and 46.97 (6.67) mg in groups P300, P600, and C, respectively (P < 0.001). VAS-PI scores at movement and at rest in the PACU and at 2, 4, and 6 hours decreased in group P600 (P < 0.01). In the PACU and at 2, 4, and 6 hours, the sedation scores were increased in group P600 compared with the scores in group C (P < 0.001, P < 0.001, P = 0.01, P = 0.006, respectively). Patient satisfaction was higher in group P600 than in group C for all time points (P < 0.001, P < 0.001, P < 0.001, P = 0.001, P < 0.001, respectively). There were no statistically significant differences between the groups for side effects such as nausea, vomiting, and dizziness (P = 0.58). CONCLUSIONS: Pregabalin at a total dose of 600 mg, administered before operation and at 12 hours postoperatively after abdominal hysterectomy, reduced morphine consumption and pain intensity and increased patient satisfaction. No significant differences in side effects were observed between the study groups. (Curr Ther Res Clin Exp. 2011;72:173-183) (C) 2011 Elsevier HS Journals, Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.curtheres.2011.06.004
dc.identifier.endpage183en_US
dc.identifier.issn0011-393X
dc.identifier.issue4en_US
dc.identifier.pmid24648587en_US
dc.identifier.scopus2-s2.0-80051594590en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage173en_US
dc.identifier.urihttps://doi.org/10.1016/j.curtheres.2011.06.004
dc.identifier.urihttps://hdl.handle.net/11616/95405
dc.identifier.volume72en_US
dc.identifier.wosWOS:000294576000004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofCurrent Therapeutic Research-Clinical and Experimentalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectmorphine consumptionen_US
dc.subjectpainen_US
dc.subjectpostoperativeen_US
dc.subjectpregabalinen_US
dc.titleEffects of 2 Different Doses of Pregabalin on Morphine Consumption and Pain After Abdominal Hysterectomy: A Randomized, Double-Blind Clinical Trialen_US
dc.typeArticleen_US

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