Prevalence of celiac disease in parents of preterm or low birthweight newborns

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dc.authoridözgör, bilge/0000-0002-6697-7629
dc.authorwosidSeckin, Yuksel/ABI-3468-2020
dc.authorwosidözgör, bilge/ABI-8272-2020
dc.contributor.authorOzgor, Bilge
dc.contributor.authorSelimoglu, Mukadder Ayse
dc.contributor.authorTemel, Ismail
dc.contributor.authorSeckin, Yuksel
dc.contributor.authorKafkasli, Ayse
dc.date.accessioned2024-08-04T20:35:46Z
dc.date.available2024-08-04T20:35:46Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: Celiac disease (CD) may present with atypical symptoms, including poor pregnancy outcomes, such as preterm and low birthweight (LBW) deliveries, thus we aimed to investigate the frequency of CD in mothers and fathers of preterm or LBW newborns. Materials and Methods: In this study, 316 parents of 164 preterm or LBW newborns and 246 parents of 123 healthy newborns were included. CD was screened using tissue transglutaminase immunoglobulin A. Endoscopic duodenal biopsy was provided in the seropositive cases. Results: Positive tissue transglutaminase immunoglobulin A was found in six (1.1%; 1/94) individuals (three mothers and three fathers); five were from the study group (1.6%; 1/63) and one was from the control group (0.4%; 1/246). CD prevalence in mothers, fathers and parents of preterm newborns was 1/57 (1.8%), 1/57 (1.8%) and 1/29 (3.5%), respectively. In the LBW group, seropositivity in fathers was 1/50 (2%) with no seropositive mothers. Biopsy-proven CD was found in 1/159 mothers (0.6%) and 1/79 fathers (1.3%). Mean birthweights of the newborns of seropositive mothers and fathers were 214 g (P < 0.05) and 320 g lower than those of seronegative ones, respectively. However, in logistic regression analysis it was found that seropositivity of mothers or fathers did not affect gestational age or birthweight of the newborns. Conclusion: Because the prevalence of CD in parents of preterm or LBW newborns is not statistically higher than the healthy population, routine CD screening in that group cannot be recommended at the time being. For more definite conclusions further studies are needed.en_US
dc.description.sponsorshipInonu University Scientific Research Projects Uniten_US
dc.description.sponsorshipThis study was funded by Inonu University Scientific Research Projects Unit (No: 2007/03). All authors guarantee: (i) that the article has not been published elsewhere; (ii) it is not being considered for publication elsewhere; and (iii) that it has been submitted with the full knowledge and approval of the institution or organization given as the affiliation of the author(s).en_US
dc.identifier.doi10.1111/j.1447-0756.2011.01584.x
dc.identifier.endpage1619en_US
dc.identifier.issn1341-8076
dc.identifier.issn1447-0756
dc.identifier.issue11en_US
dc.identifier.pmid21733039en_US
dc.identifier.scopus2-s2.0-84857429385en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1615en_US
dc.identifier.urihttps://doi.org/10.1111/j.1447-0756.2011.01584.x
dc.identifier.urihttps://hdl.handle.net/11616/95578
dc.identifier.volume37en_US
dc.identifier.wosWOS:000298013300015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Obstetrics and Gynaecology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectceliac diseaseen_US
dc.subjectlow birthweighten_US
dc.subjectpretermen_US
dc.subjectprevalenceen_US
dc.titlePrevalence of celiac disease in parents of preterm or low birthweight newbornsen_US
dc.typeArticleen_US

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