Efficacy of Intravenous Ibuprofen and Intravenous Paracetamol in Multimodal Pain Management of Postoperative Pain After Percutaneous Nephrolithotomy

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dc.authoridUçar, Muharrem/0000-0002-1232-9829
dc.authoridcolak, yusuf ziya/0000-0002-8729-8705
dc.authoriderdogan, mehmet ali/0000-0002-1713-5695
dc.authoridOZGUL, Ulku/0000-0003-3738-1751
dc.authorwosidUçar, Muharrem/ABH-7761-2020
dc.authorwosidcolak, yusuf ziya/ABH-3032-2020
dc.authorwosiderdogan, mehmet ali/ABI-4675-2020
dc.authorwosidOZGUL, Ulku/ABI-6823-2020
dc.contributor.authorUcar, Muharrem
dc.contributor.authorErdogan, Mehmet Ali
dc.contributor.authorSanli, Mukadder
dc.contributor.authorColak, Yusuf Ziya
dc.contributor.authorAydogan, Mustafa Said
dc.contributor.authorYucel, Aytac
dc.contributor.authorOzgul, Ulku
dc.date.accessioned2024-08-04T20:51:46Z
dc.date.available2024-08-04T20:51:46Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: Many different techniques, including multimodal analgesia, have been used for the management of postoperative pain after Percutaneous nephrolithotomy (PCNL). Ketorolac, intravenous (IV) paracetamol, rofecoxib, and IV ibuprofen have been used as a part of a multimodal analgesic approach in different surgical procedures. However, the efficacy of IV ibuprofen has not been well elucidated in adult patients undergoing elective PCNL. The aim of the study was to examine the efficacy of IV ibuprofen compared to IV paracetamol after elective PCNL. Design: This was a prospective randomized clinic study. Methods: The study was conducted with 50 patients scheduled for PNCL between the ages of 18 and 65. IV ibuprofen 800 mg infusion was used for Group I, and 1 g IV paracetamol infusion Group P. IV tramadol infusion was administered with a Patient Controlled Analgesia device for postoperative analgesia. The primary outcome was 24-hour tramadol consumption. Secondary outcomes were pain intensity and side effects of the drugs. All outcomes were recorded in the 30th minute in the PACU and in 2, 4, 6, 12, 24 hours postoperatively. Findings: Total postoperative tramadol consumption was significantly lower in Group I compared with Group P (P = .031). There was also a significant decrease in the cumulative tramadol consumption between the two groups in the 2nd and 24th hours (P < .012). In all measurement periods, pain intensity, sedation score, nausea and vomiting, itching, additional analgesia, and satisfaction with pain management were similar between the two groups. Conclusion: IV ibuprofen, used as a part of multimodal tramadol-based analgesia reduced tramadol consumption compared with IV paracetamol in the first 24 hours postoperatively after elective PCNL. The IV ibuprofen-tramadol combination seems appeared superior to a paracetamol-tramadol combination. (C) 2021 American Society of PeriAnesthesia Nurses. Published by Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipInonu University Scientific Research Projects Coordination Unit [2016/67]en_US
dc.description.sponsorshipIt was supported by Inonu University Scientific Research Projects Coordination Unit with project number 2016/67.en_US
dc.identifier.doi10.1016/j.jopan.2021.10.018
dc.identifier.endpage544en_US
dc.identifier.issn1089-9472
dc.identifier.issn1532-8473
dc.identifier.issue4en_US
dc.identifier.pmid35305913en_US
dc.identifier.scopus2-s2.0-85126554779en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage540en_US
dc.identifier.urihttps://doi.org/10.1016/j.jopan.2021.10.018
dc.identifier.urihttps://hdl.handle.net/11616/100541
dc.identifier.volume37en_US
dc.identifier.wosWOS:000842462800082en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofJournal of Perianesthesia Nursingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectibuprofenen_US
dc.subjectintravenousen_US
dc.subjectpostoperative painen_US
dc.subjectparacetamolen_US
dc.subjectanalgesiaen_US
dc.titleEfficacy of Intravenous Ibuprofen and Intravenous Paracetamol in Multimodal Pain Management of Postoperative Pain After Percutaneous Nephrolithotomyen_US
dc.typeArticleen_US

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