Harmful Effects of Formaldehyde and Possible Protective Effect of Nigella sativa on the Trachea of Rats

Basit Öğe Kaydı
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridUysal, Murat/0000-0003-0717-4428
dc.authoridtoplu, yuksel/0000-0002-5444-557X
dc.authoridsapmaz, emrah/0000-0002-0346-8704
dc.authorwosidToplu, Yuksel/AAA-3133-2021
dc.authorwosidArıcı, Akgül/JJE-3376-2023
dc.authorwosidVardı, Nigar/C-9549-2018
dc.contributor.authorSapmaz, E.
dc.contributor.authorSapmaz, H. I.
dc.contributor.authorVardi, N.
dc.contributor.authorTas, U.
dc.contributor.authorSarsilmaz, M.
dc.contributor.authorToplu, Y.
dc.contributor.authorArici, A.
dc.date.accessioned2024-08-04T20:43:10Z
dc.date.available2024-08-04T20:43:10Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: We aimed in this study to investigate the harmful effects of formaldehyde (FA) inhalation and possible protective effects of Nigella sativa (NS) on rats' trachea. Materials and Methods: In this study, 63 adult male rats were used. Animals were divided into nine groups. Group I was used as control group. All other groups were exposed to FA inhalation. Group III, V, VII, and IX were administered NS by gavage. Tissues were examined histologically, and immunohistochemical examination for Bax and caspase-3 immunoreactivity was carried out. Results: Our study demonstrated that FA caused apoptosis in the tracheal epithelial cells. The most apoptotic activity occurred at a 10 ppm dose in a 13-week exposure. Distortion of tracheal epithelium and cilia loss on epithelial surface was present in all groups. However, NS treated Groups VII and IX had decreased apoptotic activity and lymphoid infiltration and protected the epithelial structure, despite some shedded areas. Difference of tracheal epithelial thickness and histological score was statistically significant between Group VI-VII and VIII-IX. Conclusion: FA induces apoptosis and tracheal epithelial damage in rats, and chronic administration of NS can be used to prevent FA-induced apoptosis and epithelial damage.en_US
dc.identifier.doi10.4103/1119-3077.183253
dc.identifier.endpage529en_US
dc.identifier.issn1119-3077
dc.identifier.issue5en_US
dc.identifier.pmid28513508en_US
dc.identifier.scopus2-s2.0-85019651884en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage523en_US
dc.identifier.urihttps://doi.org/10.4103/1119-3077.183253
dc.identifier.urihttps://hdl.handle.net/11616/97825
dc.identifier.volume20en_US
dc.identifier.wosWOS:000402418200004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofNigerian Journal of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectformaldehydeen_US
dc.subjectNigella sativaen_US
dc.subjectraten_US
dc.subjecttracheaen_US
dc.titleHarmful Effects of Formaldehyde and Possible Protective Effect of Nigella sativa on the Trachea of Ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu