Effects of the apricot diets containing sulfur dioxide at different concentrations on rat testicles

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dc.authoridUlu, Ahmet/0000-0002-4447-6233
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridUğur, Yılmaz/0000-0002-9040-4249
dc.authoridTaslidere, Elif/0000-0003-1723-2556
dc.authoridPolat, Seyhan/0000-0002-8766-9094
dc.authoridOzhan, Onural/0000-0001-9018-7849
dc.authorwosidUlu, Ahmet/L-5180-2016
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidUğur, Yılmaz/AAA-4699-2022
dc.authorwosidTaslidere, Elif/ABI-8046-2020
dc.authorwosidPolat, Seyhan/JLL-4491-2023
dc.authorwosidOzhan, Onural/AAE-2356-2020
dc.contributor.authorYildiz, Azibe
dc.contributor.authorOzhan, Onural
dc.contributor.authorUlu, Ahmet
dc.contributor.authorDogan, Tugba
dc.contributor.authorBakar, Busra
dc.contributor.authorUgur, Yilmaz
dc.contributor.authorTaslidere, Elif
dc.date.accessioned2024-08-04T20:53:43Z
dc.date.available2024-08-04T20:53:43Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractDue to its antioxidant and antimicrobial properties, sulfur dioxide (SO2) is widely used in foods and beverages to prevent the growth of microorganisms and to preserve the color and flavor of fruits. However, the amount of SO2 used in fruit preservation should be limited due to its possible adverse effects on human health. The present study was designed to investigate the effects of different SO2 concentrations in apricot diets on rat testes. Animals were randomly divided into six groups. The control group was fed a standard diet, and the other groups were fed apricot diet pellets prepared with (w/w) 10% dried apricots containing SO2 at different concentrations (1500 ppm, 2000 ppm, 2500 ppm, 3000 ppm, and 3500 ppm/kg) for 24 weeks. After sacrification, testicles were evaluated biochemically, histopathologically, and immunohistopathologically. Our results showed that an apricot diet containing 1500 ppm and 2000 ppm SO2 did not cause significant changes in testis. However, it was determined that tissue testosterone levels decreased as the amount of SO2 (2500 ppm and above) increased. Apricot diet containing 3500 ppm SO2 caused a significant increase in spermatogenic cell apoptosis, oxidative damage, and histopathological changes. In addition, a decrease in the expression of connexin-43, vimentin, and 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD) was observed in the same group. In summary, the results show that sulfurization of apricot at high concentrations such as 3500 ppm may lead to male fertility problems in the long term through mechanisms such as oxidative stress, spermatogenic cell apoptosis, and inhibition of steroidogenesis.en_US
dc.identifier.doi10.1007/s11356-023-27692-w
dc.identifier.endpage74313en_US
dc.identifier.issn0944-1344
dc.identifier.issn1614-7499
dc.identifier.issue29en_US
dc.identifier.pmid37204578en_US
dc.identifier.scopus2-s2.0-85159656177en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage74301en_US
dc.identifier.urihttps://doi.org/10.1007/s11356-023-27692-w
dc.identifier.urihttps://hdl.handle.net/11616/101359
dc.identifier.volume30en_US
dc.identifier.wosWOS:000992741600005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofEnvironmental Science and Pollution Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSulfur dioxideen_US
dc.subjectDried apricoten_US
dc.subjectOxidative stressen_US
dc.subjectHistopathologyen_US
dc.subjectImmunohistopathologyen_US
dc.subjectTestisen_US
dc.titleEffects of the apricot diets containing sulfur dioxide at different concentrations on rat testiclesen_US
dc.typeArticleen_US

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