subchronic effects of sublethal exposure of azinphos-methyl on swiss albino mice

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dc.authorscopusid10641512200
dc.contributor.authorBalli Ş.
dc.date.accessioned2024-08-04T20:00:54Z
dc.date.available2024-08-04T20:00:54Z
dc.date.issued1996
dc.departmentİnönü Üniversitesien_US
dc.description.abstractSubchronic effects of azinphos-methyl. an organophosphorus pesticide, was investigated on swiss-albino mice (Mus musculus) under the laboratory conditions in this study. Different tissues were used for histological preparations and also plasma cholinesterase (ChE) activity was determined by spectrophotometric assay for F1 generation. Totally 29 mice were used for the ChE activity assays. Insecticide was added to drinking water (ad libitum) as 1.0 ppm or 0.1 ppm sublethal doses for 14 weeks. Results were compared with control group. Histopathological changes in the liver, kidney and brain tissues were determined using a light microscope. Plasma cholinesterase activity was inhibited 52.14% on males and 41.29% on females in 1.0 ppm exposure group and activity inhibition were occured at 31.0% and 29.84% respectively for 0.1 ppm exposure level. Enzymatic activity was found to be istatistically different between the control and treatment groups for male and female mice (P<0.001. P<0.02). Some histopathological changes, like necrosis, congestion, increase of the mitotic activity, enlargement of the sinusoids and pleomorphism of the hepatocytes, have been detected on liver tissues for both exposure groups, depending on the doses. However histologically no significant differences were found for kidney and brain tissues compared with treatment and control groups. © TÜBITAK.en_US
dc.identifier.endpage93en_US
dc.identifier.issn1300-0179
dc.identifier.issueSUPPL.en_US
dc.identifier.scopus2-s2.0-29744454198en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage89en_US
dc.identifier.urihttps://hdl.handle.net/11616/91089
dc.identifier.volume20en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofTurkish Journal of Zoologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAzinphos-methylen_US
dc.subjectCholinesteraseen_US
dc.subjectHistopathologyen_US
dc.subjectSubchronic Effecten_US
dc.titlesubchronic effects of sublethal exposure of azinphos-methyl on swiss albino miceen_US
dc.title.alternativeSubletal Dozda Azinphos-Methyl Uygulanmasinin Albino Farelerde Subkronik Etkilerien_US
dc.typeArticleen_US

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