The role of Nrf2/SIRT1 pathway in the hepatoprotective effect of PEITC against HFD/STZ-induced diabetic liver disease

Basit Öğe Kaydı
dc.contributor.authorAtıcı, Buğrahan
dc.contributor.authorUyumlu, Ayşe Burçin
dc.contributor.authorTaşdemir, Aslı
dc.date.accessioned2024-08-04T19:42:42Z
dc.date.available2024-08-04T19:42:42Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: We intended to assess the hepatoprotective effects of phenethyl isothiocyanate (PEITC) against oxidative liver injury induced by a high-fat diet (HFD) and streptozotocin (STZ) diabetes through the Nuclear Factor E2-Related Factor 2 (Nrf2) and Sirtuin 1 (SIRT1) pathways in rats. Materials and Methods: Thirty male Wistar Albino rats were separated into three groups: the control group, the second group (HFD+STZ) fed HFD and injected with STZ (35mg/kg b.w.), and the third group (HFD+ STZ+PEITC) fed an HFD, injected with STZ (35mg/kg b.w.), and given PEITC (40mg/kg b.w. by oral gavage). Feeding with HFD and PEITC was given for two weeks and continued one more week following STZ. Serum ALT and lipids levels, antioxidant enzyme activities, MDA, GST, SIRT1, NF-??, and Nrf2 levels were measured. Liver histological changes were detected. Results: In comparison with the control group, in the HFD+STZ group, serum HDL levels, activities of hepatic antioxidant enzymes, Nrf2 activity, levels of GST, SIRT1, and NF-?? reduced and besides, serum ALT, TG, TC, LDL / VLDL, and hepatic MDA levels increased (p <0.05). PEITC pre-administration led to improvement in these changes made by HFD-STZ (p <0.05). Conclusion: Our data presented that PEITC ameliorated hepatic injury and serum lipid profile induced by HFD and STZ via the activation of Nrf2 and SIRT1 pathways. We can suggest that PEITC could be a possible candidate agent against liver diseases.en_US
dc.identifier.doi10.5455/annalsmedres.2022.04.118
dc.identifier.endpage1353en_US
dc.identifier.issn2636-7688
dc.identifier.issue12en_US
dc.identifier.startpage1348en_US
dc.identifier.trdizinid1165248en_US
dc.identifier.urihttps://doi.org/10.5455/annalsmedres.2022.04.118
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1165248
dc.identifier.urihttps://hdl.handle.net/11616/88580
dc.identifier.volume29en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofAnnals of Medical Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe role of Nrf2/SIRT1 pathway in the hepatoprotective effect of PEITC against HFD/STZ-induced diabetic liver diseaseen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu